Malev Olga, Trebše Polonca, Piecha Małgorzata, Novak Sara, Budič Bojan, Dramićanin Miroslav D, Drobne Damjana
University of Nova Gorica, 5000, Nova Gorica, Slovenia.
Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000, Ljubljana, Slovenia.
Arch Environ Contam Toxicol. 2017 Feb;72(2):303-311. doi: 10.1007/s00244-017-0363-3. Epub 2017 Jan 19.
Nano-sized cerium dioxide (CeO) particles are emerging as an environmental issue due to their extensive use in automobile industries as fuel additives. Limited information is available on the potential toxicity of CeO nanoparticles (NPs) on terrestrial invertebrates through dietary exposure. In the present study, the toxic effects of CeO NPs on the model soil organism Porcellio scaber were evaluated. Nanotoxicity was assessed by monitoring the lipid peroxidation (LP) level and feeding rate after 14-days exposure to food amended with nano CeO. The exposure concentration of 1000 μg of CeO NPs g dry weight food for 14 days significantly increased both the feeding rate and LP. Thus, this exposure dose is considered the lowest observed effect dose. At higher exposure doses of 2000 and 5000 μg of CeO NPs g dry weight food, NPs significantly decreased the feeding rate and increased the LP level. Comparative studies showed that CeO NPs are more biologically potent than TiO NPs, ZnO NPs, CuO NPs, CoFeO NPs, and Ag NPs based on feeding rate using the same model organism and experimental setup. Based on comparative metal oxide NPs toxicities, the present results contribute to the knowledge related to the ecotoxicological effects of CeO NPs in terrestrial invertebrates exposed through feeding.
纳米二氧化铈（CeO）颗粒因其在汽车工业中作为燃料添加剂的广泛使用而成为一个环境问题。关于CeO纳米颗粒（NPs）通过饮食暴露对陆生无脊椎动物潜在毒性的信息有限。在本研究中，评估了CeO NPs对模式土壤生物鼠妇（Porcellio scaber）的毒性作用。通过监测暴露于添加纳米CeO的食物14天后的脂质过氧化（LP）水平和摄食率来评估纳米毒性。在1000μg CeO NPs/克干重食物的暴露浓度下暴露14天，显著提高了摄食率和LP。因此，该暴露剂量被认为是最低观察效应剂量。在2000和5000μg CeO NPs/克干重食物的更高暴露剂量下，NPs显著降低了摄食率并提高了LP水平。比较研究表明，基于使用相同模式生物和实验装置的摄食率，CeO NPs比TiO NPs、ZnO NPs、CuO NPs、CoFeO NPs和Ag NPs具有更强的生物活性。基于对金属氧化物NPs毒性的比较，本研究结果有助于了解CeO NPs对通过摄食暴露的陆生无脊椎动物的生态毒理学效应。
