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3D打印在复杂脊柱疾病手术规划和定制患者植入物设计中的应用:病例报告

The utility of 3D printing for surgical planning and patient-specific implant design for complex spinal pathologies: case report.

出版信息

J Neurosurg Spine. 2017 Apr;26(4):513-518. doi: 10.3171/2016.9.SPINE16371. Epub 2017 Jan 20.

DOI:10.3171/2016.9.SPINE16371
PMID:28106524
Abstract

OBJECTIVE There has been a recent renewed interest in the use and potential applications of 3D printing in the assistance of surgical planning and the development of personalized prostheses. There have been few reports on the use of 3D printing for implants designed to be used in complex spinal surgery. METHODS The authors report 2 cases in which 3D printing was used for surgical planning as a preoperative mold, and for a custom-designed titanium prosthesis: one patient with a C-1/C-2 chordoma who underwent tumor resection and vertebral reconstruction, and another patient with a custom-designed titanium anterior fusion cage for an unusual congenital spinal deformity. RESULTS In both presented cases, the custom-designed and custom-built implants were easily slotted into position, which facilitated the surgery and shortened the procedure time, avoiding further complex reconstruction such as harvesting rib or fibular grafts and fashioning these grafts intraoperatively to fit the defect. Radiological follow-up for both cases demonstrated successful fusion at 9 and 12 months, respectively. CONCLUSIONS These cases demonstrate the feasibility of the use of 3D modeling and printing to develop personalized prostheses and can ease the difficulty of complex spinal surgery. Possible future directions of research include the combination of 3D-printed implants and biologics, as well as the development of bioceramic composites and custom implants for load-bearing purposes.

摘要

目的 近期,3D打印在辅助手术规划及个性化假体研发中的应用及潜在用途再度引发关注。关于3D打印在复杂脊柱手术植入物中的应用报道较少。方法 作者报告2例3D打印用于手术规划(作为术前模具)及定制钛制假体的病例:1例C-1/C-2脊索瘤患者接受肿瘤切除及椎体重建,另1例为因特殊先天性脊柱畸形使用定制钛制前路融合器的患者。结果 在这2例病例中,定制设计和制造的植入物均能轻松就位,这有利于手术并缩短了手术时间,避免了进一步复杂的重建操作,如取肋骨或腓骨移植物并在术中对这些移植物进行塑形以适应缺损。2例病例的影像学随访分别显示在9个月和12个月时成功融合。结论 这些病例证明了使用3D建模和打印来开发个性化假体的可行性,并可减轻复杂脊柱手术的难度。未来可能的研究方向包括3D打印植入物与生物制剂的结合,以及用于承重目的的生物陶瓷复合材料和定制植入物的研发。

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