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15-deoxy-Δ12,14-prostaglandin J2 in neurodegenerative diseases and cancers.

作者信息

Yagami Tatsurou, Yamamoto Yasuhiro, Koma Hiromi

机构信息

Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Japan.

出版信息

Oncotarget. 2017 Feb 7;8(6):9007-9008. doi: 10.18632/oncotarget.14701.

DOI:10.18632/oncotarget.14701
PMID:28107188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5354706/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd7/5354706/e85aa54f9837/oncotarget-08-9007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd7/5354706/e85aa54f9837/oncotarget-08-9007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd7/5354706/e85aa54f9837/oncotarget-08-9007-g001.jpg

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Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion.非诺贝特、曲格列酮和15-脱氧-Δ12,14-前列腺素J2可关闭ATP敏感性钾通道并诱导胰岛素分泌。
J Pharmacol Exp Ther. 2004 Sep;310(3):1273-80. doi: 10.1124/jpet.104.067249. Epub 2004 Jun 16.
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The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry.15-脱氧-Δ12,14-前列腺素J2的首次全合成及C14立体化学的明确归属。
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本文引用的文献

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15-Deoxy-Δ-prostaglandin J induced neurotoxicity via suppressing phosphoinositide 3-kinase.15-脱氧-Δ-前列腺素J通过抑制磷酸肌醇3-激酶诱导神经毒性。
Neuropharmacology. 2017 Feb;113(Pt A):416-425. doi: 10.1016/j.neuropharm.2016.10.017. Epub 2016 Oct 19.
2
Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System.环氧化酶和前列腺素在中枢神经系统中的病理生理作用
Mol Neurobiol. 2016 Sep;53(7):4754-71. doi: 10.1007/s12035-015-9355-3. Epub 2015 Sep 2.
3
Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma.
抗神经元特异性烯醇化酶抗体以新颖的方式诱导神经元细胞死亡。
Mol Neurobiol. 2020 May;57(5):2265-2278. doi: 10.1007/s12035-020-01876-8. Epub 2020 Jan 31.
4
Peroxisomes and Oxidative Stress: Their Implications in the Modulation of Cellular Immunity During Mycobacterial Infection.过氧化物酶体与氧化应激:它们在分枝杆菌感染期间对细胞免疫调节的影响
Front Microbiol. 2019 Jun 14;10:1121. doi: 10.3389/fmicb.2019.01121. eCollection 2019.
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15-deoxy-Δ-prostaglandin J enhances anticancer activities independently of VHL status in renal cell carcinomas.15-脱氧-Δ-前列腺素J在肾细胞癌中独立于VHL状态增强抗癌活性。
Biochem Biophys Rep. 2019 Feb 14;18:100608. doi: 10.1016/j.bbrep.2019.01.001. eCollection 2019 Jul.
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Pathophysiological Roles of Intracellular Proteases in Neuronal Development and Neurological Diseases.细胞内蛋白酶在神经元发育和神经疾病中的病理生理作用。
Mol Neurobiol. 2019 May;56(5):3090-3112. doi: 10.1007/s12035-018-1277-4. Epub 2018 Aug 10.
15-脱氧-Δ(12,14)-前列腺素 J2 通过 PPARγ 非依赖性途径的细胞毒性作用及 JNK 和 Akt 途径在肾细胞癌中的作用。
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15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways.15-脱氧-Δ12,14-前列腺素 J2 独立于拓扑异构酶-II 和 PPARγ 途径增强了喜树碱对肾细胞癌的抗肿瘤活性。
Biochem Biophys Res Commun. 2011 Jul 8;410(3):563-7. doi: 10.1016/j.bbrc.2011.06.026. Epub 2011 Jun 12.
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Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice.炎症产物前列腺素J2的亚慢性输注可在小鼠中模拟散发性帕金森病。
J Neuroinflammation. 2009 Jul 25;6:18. doi: 10.1186/1742-2094-6-18.
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Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region.磷脂酰肌醇3激酶是海马CA1区长期增强效应表达所必需的,但不是其诱导或维持所必需的。
J Neurosci. 2002 May 1;22(9):3359-65. doi: 10.1523/JNEUROSCI.22-09-03359.2002.
7
Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death.新型非甾体抗炎药S-2474对β-淀粉样蛋白诱导的神经元细胞死亡的影响。
Br J Pharmacol. 2001 Oct;134(3):673-81. doi: 10.1038/sj.bjp.0704261.
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The formation of prostaglandins in the postmortem cerebral cortex of Alzheimer-type dementia patients.阿尔茨海默型痴呆患者死后大脑皮质中前列腺素的形成。
J Neurol. 1989 Feb;236(2):80-4. doi: 10.1007/BF00314401.