Kramer John L K, Geisler Fred, Ramer Leanne, Plunet Ward, Cragg Jacquelyn J
1 University of British Columbia, Vancouver, British Columbia, Canada.
2 Rhausler, Inc, Can Carlos, CA, USA.
Neurorehabil Neural Repair. 2017 May;31(5):399-401. doi: 10.1177/1545968316688801. Epub 2017 Jan 20.
Recovery from acute spinal cord injury (SCI) is characterized by extensive heterogeneity, resulting in uncertain prognosis. Reliable prediction of recovery in the acute phase benefits patients and their families directly, as well as improves the likelihood of detecting efficacy in clinical trials. This issue of heterogeneity is not unique to SCI. In fields such as traumatic brain injury, Parkinson's disease, and amyotrophic lateral sclerosis, one approach to understand variability in recovery has been to make clinical trial data widely available to the greater research community. We contend that the SCI community should adopt a similar approach in providing open access clinical trial data.
急性脊髓损伤(SCI)的恢复具有广泛的异质性,导致预后不确定。急性期恢复情况的可靠预测对患者及其家属有直接益处,同时也提高了在临床试验中检测疗效的可能性。这种异质性问题并非脊髓损伤所特有。在创伤性脑损伤、帕金森病和肌萎缩侧索硬化等领域,一种理解恢复变异性的方法是向更广泛的研究群体广泛提供临床试验数据。我们认为,脊髓损伤领域应采用类似方法,提供开放获取的临床试验数据。