Alim Sait, Esen Mehmet, Demir Ayşe Kevser, Demir Selim, Ortak Hüseyin, Güneş Alper, Alatli Tufan, Deniz Demir Helin
Department of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Department of Emergency Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Int Ophthalmol. 2018 Feb;38(1):183-190. doi: 10.1007/s10792-017-0446-1. Epub 2017 Jan 21.
The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell-inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF).
Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography. The patients were divided into two groups according to their disease severity score, M694V gene mutation, colchicine dosage used per day, colchicine usage time period and number of FMF attacks per year.
There were no statistically significant differences in peripapillary RNFL and retinal GCIPL thickness in patients with adult-onset FMF and controls.
According to our study, it looks like that neither adult-onset FMF nor colchicine has any effect on the RNFL and GCIPL thicknesses. Further studies with a large sample size are needed.
本研究旨在评估成年起病型家族性地中海热（FMF）患者视乳头周围视网膜神经纤维层（RNFL）和视网膜神经节细胞-内丛状层（GCIPL）的厚度。
本研究纳入了42例成年起病型FMF患者和42例健康对照者。进行了详细的眼部检查，然后通过光谱域光学相干断层扫描测量视乳头周围RNFL和GCIPL的厚度。根据患者的疾病严重程度评分、M694V基因突变、每日使用秋水仙碱的剂量、秋水仙碱使用时间段以及每年FMF发作次数将患者分为两组。
成年起病型FMF患者与对照组在视乳头周围RNFL和视网膜GCIPL厚度方面无统计学显著差异。
根据我们的研究，成年起病型FMF和秋水仙碱似乎对视乳头周围RNFL和视网膜GCIPL厚度均无影响。需要进行更大样本量的进一步研究。
