Tanyıldız Burak, Tezcan Mehmet Engin, Kandemir Baran, Günaydın Nesrin Tutaş, Göktaş Eren, Tangılntız Aise, Arsan Aysu Karatay
Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Ophthalmology, Semsi Denizer Caddesi, E-5, 34890, Kartal Istanbul, Turkey.
Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Rheumatology, Istanbul, Turkey.
BMC Ophthalmol. 2018 Feb 5;18(1):27. doi: 10.1186/s12886-018-0698-1.
The purpose of this study is to investigate whether oral colchicine has an effect on peripapillary retinal nerve fiber layer (pRNFL) thickness of familial Mediterranean fever (FMF) patients.
We conducted a cross sectional study by comparing pRNFL thickness of FMF patients on colchicine (treated group), newly diagnosed colchicine naïve FMF patients (untreated group) and healthy controls. The study included 66 FMF patients and 32 healthy control subjects. Treated FMF patients were grouped according to colchicine use, duration of use and dosage. pRNFL thickness of the patients and controls were measured by using optical coherence tomography and the measurements were compared.
No statistically significant difference was found between the pRNFL thickness in untreated group, treated group and the healthy control group (all p > 0.05). No statistically significant difference was found between pRNFL thickness in the healthy control group and FMF patients grouped according to duration or dosage of colchicine use (all p > 0.05).
According to our study, FMF and oral colchicine use had no statistically significant effect on pRNFL thickness.
本研究旨在调查口服秋水仙碱对家族性地中海热（FMF）患者的视乳头周围视网膜神经纤维层（pRNFL）厚度是否有影响。
我们通过比较服用秋水仙碱的FMF患者（治疗组）、新诊断的未服用秋水仙碱的FMF患者（未治疗组）和健康对照者的pRNFL厚度进行了一项横断面研究。该研究纳入了66例FMF患者和32例健康对照者。治疗的FMF患者根据秋水仙碱的使用情况、使用持续时间和剂量进行分组。使用光学相干断层扫描测量患者和对照者的pRNFL厚度，并对测量结果进行比较。
未治疗组、治疗组和健康对照组的pRNFL厚度之间未发现统计学上的显著差异（所有p>0.05）。健康对照组与根据秋水仙碱使用持续时间或剂量分组的FMF患者的pRNFL厚度之间未发现统计学上的显著差异（所有p>0.05）。
根据我们的研究，FMF和口服秋水仙碱的使用对pRNFL厚度没有统计学上的显著影响。
