Sawada Kazuhiko, Fukunishi Katsuhiro, Kashima Masatoshi, Imai Noritaka, Saito Shigeyoshi, Aoki Ichio, Fukui Yoshihiro
Department of Nutrition, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki, Japan.
Department of Anatomy and Developmental Neurobiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Congenit Anom (Kyoto). 2017 Jul;57(4):114-117. doi: 10.1111/cga.12209. Epub 2017 Mar 28.
The present study aimed to specify the cerebral sulci developed by cortical expansion in cynomolgus monkey fetuses. The degree of sulcal infolding was evaluated by the gyrification index (GI), which was quantified using ex vivo magnetic resonance imaging. The correlation of cortical volume with the sulcal GI was most frequent during embryonic days (EDs) 100 to 120. Interestingly, the high correlation was marked during EDs 140 to 150 in restricted primary sulci in prefrontal, parietotemporal and medial temporal regions. The present results suggest that cortical expansion is involved in gyral demarcation by sulcal infolding, followed by the sulcal infolding progression in phylogenetically-newer cortices.
本研究旨在明确食蟹猴胎儿中由皮质扩张形成的脑沟。通过脑回形成指数（GI）评估脑沟折叠程度，该指数使用离体磁共振成像进行量化。皮质体积与脑沟GI的相关性在胚胎期（EDs）100至120天最为常见。有趣的是，在额叶前部、顶颞叶和颞叶内侧的受限主要脑沟中，EDs 140至150天期间相关性较高。本研究结果表明，皮质扩张参与了脑沟折叠形成的脑回划分，随后在系统发育较新的皮质中脑沟折叠继续发展。
