Department of Physical Therapy, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki, Japan.
Neuroscience. 2010 May 19;167(3):735-40. doi: 10.1016/j.neuroscience.2010.02.045. Epub 2010 Feb 26.
The ontogenetic pattern of gyrification and its relationship with cerebral cortical volume were examined in cynomolgus monkey fetuses. T(1)-weighted coronal magnetic resonance (MR) images at 7 T were acquired from the fixed cerebra of three male fetuses, each at embryonic days (EDs) 70 to 150, and the gyrification index (GI) of each slice was estimated. The mean GI was low (1.1-1.2) during EDs 70 to 90, and then increased dramatically on ED 100. The developmental profiles of the rostrocaudal GI distribution revealed that cortical convolution was more frequent in the parietooccipital region than in other regions during EDs 100 to 150, forming an adult-like pattern by ED 150. The mean GI was closely correlated with the volume of cortical gray matter (r=0.9877), and also with the volume of white matter/intermediate zone (r=0.8961). These findings suggest that cortical convolution is correlated with either the maturation of cortical gray matter or the development of white matter bundles. The characteristic GI distribution pattern of catarrhines was formed by ED 150 in correlation with the progressive sulcal infolding in the parietooccipital region of the cerebrum.
我们研究了食蟹猴胎儿脑回发育模式及其与大脑皮质体积的关系。我们在 7T 下对 3 只雄性胎儿的固定大脑进行了 T1 加权冠状磁共振（MR）成像，每个胎儿的采集时间为胚胎日（ED）70 至 150 天，并对每个切片的脑回指数（GI）进行了估计。ED70 至 90 天期间，平均 GI 较低（1.1-1.2），然后在 ED100 时急剧增加。从额至尾的 GI 分布发育情况来看，在 ED100 至 150 天期间，顶枕区皮质的脑回更为频繁，到 ED150 时形成了成人样模式。平均 GI 与皮质灰质体积（r=0.9877）密切相关，也与白质/中间带的体积（r=0.8961）相关。这些发现表明，脑回发育与皮质灰质的成熟或白质束的发育有关。与大脑顶枕区脑沟逐渐加深相关，灵长类动物的特征性 GI 分布模式在 ED150 时形成。
