Shibutani Y, Yokota T, Iijima S, Fujioka A, Katsuno S, Sakamoto K
Department of Hygiene, Hyogo College of Medicine, Nishinomiya, Japan.
Jpn J Med. 1989 Jul-Aug;28(4):496-502. doi: 10.2169/internalmedicine1962.28.496.
To clarify magnesium metabolism in thyroid dysfunction, plasma and erythrocyte magnesium concentrations (P-Mg, E-Mg) were determined in patients with untreated thyroid diseases and their relations to thyroid hormone levels and the duration of illness were examined. P-Mg was significantly lower in hyperthyroid patients than in euthyroid or hypothyroid individuals. E-Mg was significantly higher in hypothyroid patients than in hyperthyroid or euthyroid individuals. In the entire series of 84 subjects, both P-Mg and E-Mg showed significant negative correlations with thyroid hormone levels, but the correlations were greater in P-Mg than E-Mg. In hyperthyroid patients, both P-Mg and E-Mg were negatively correlated with the duration of illness, but this correlation was greater in E-Mg than P-Mg. Also, both P-Mg and E-Mg were significantly higher in patients with destructive thyroiditis with a short duration (0.5 months) such as subacute or painless thyroiditis than in patients with Graves' disease (4.9 months). These results suggest that magnesium metabolism in thyroid dysfunction is affected not only by thyroid hormone levels but also by the duration of illness.
为阐明甲状腺功能障碍时的镁代谢情况，我们测定了未经治疗的甲状腺疾病患者的血浆和红细胞镁浓度（P-Mg、E-Mg），并研究了它们与甲状腺激素水平及病程的关系。甲亢患者的P-Mg显著低于甲状腺功能正常或甲减患者。甲减患者的E-Mg显著高于甲亢或甲状腺功能正常的个体。在整个84例受试者系列中，P-Mg和E-Mg均与甲状腺激素水平呈显著负相关，但P-Mg的相关性大于E-Mg。在甲亢患者中，P-Mg和E-Mg均与病程呈负相关，但E-Mg的这种相关性大于P-Mg。此外，亚急性或无痛性甲状腺炎等病程较短（0.5个月）的破坏性甲状腺炎患者的P-Mg和E-Mg均显著高于格雷夫斯病患者（4.9个月）。这些结果表明，甲状腺功能障碍时的镁代谢不仅受甲状腺激素水平影响，还受病程影响。
