Yamashita Y, Hirai T, Mukaida H, Kawano K, Toge T, Niimoto M, Hattori T, Kunita T
Department of Surgery, Hiroshima University, Japan.
Jpn J Surg. 1989 Jul;19(4):498-501. doi: 10.1007/BF02471636.
An unusual case of primary esophageal melanoma is reported herein. A 68 year old man who had experienced occasional dysphagia for about one month without suffering any weight loss was admitted to our department. An esophagogram revealed two lobulated masses and esophagoscopy showed a pigmented tumor in one of the masses. Curative surgery was thus performed through a right thoracotomy. The macroscopic appearance of the resected specimen was very unusual and it was subsequently proven to be primary malignant melanoma of the esophagus by histological examination. Postoperatively, cyclophosphamide and interleukin-2 were administered intravenously, followed by lymphokine-activated killer therapy. However, multiple liver metastases were found on a CT scan, 3 months after the operation and he died about 1 month later. The operative indications for primary malignant melanoma of the esophagus are discussed in this report.
本文报告了一例罕见的原发性食管黑色素瘤病例。一名68岁男性因偶尔吞咽困难约1个月入院，无体重减轻。食管造影显示有两个分叶状肿块，食管镜检查发现其中一个肿块有色素沉着肿瘤。因此通过右胸切开术进行了根治性手术。切除标本的宏观外观非常不寻常，随后经组织学检查证实为原发性食管恶性黑色素瘤。术后静脉注射环磷酰胺和白细胞介素-2，随后进行淋巴因子激活的杀伤细胞治疗。然而，术后3个月的CT扫描发现多处肝转移，约1个月后死亡。本报告讨论了原发性食管恶性黑色素瘤的手术指征。
