Miyake Yoshihiro, Tanaka Keiko, Okubo Hitomi, Sasaki Satoshi, Furukawa Shinya, Arakawa Masashi
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan.
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan.
J Affect Disord. 2017 Mar 15;211:124-129. doi: 10.1016/j.jad.2017.01.016. Epub 2017 Jan 15.
One epidemiological study in Canada has addressed the association between zinc intake and depressive symptoms during pregnancy while another epidemiological study in Korea has examined the association between iron intake and depressive symptoms during pregnancy. The present cross-sectional study in Japan examined the association between intake of zinc, magnesium, iron, copper, and manganese and depressive symptoms during pregnancy.
Study subjects were 1745 pregnant women. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Depressive symptoms were defined as a score ≥16 on the Center for Epidemiologic Studies Depression Scale. Adjustment was made for age, gestation, region of residence, number of children, family structure, history of depression, family history of depression, smoking, secondhand smoke exposure at home and at work, employment, household income, education, body mass index, and intake of saturated fatty acids, eicosapentaenoic acid plus docosahexaenoic acid, calcium, vitamin D, and isoflavones.
In crude analysis, significant inverse associations were observed between intake levels of zinc, magnesium, iron, copper, and manganese and the prevalence of depressive symptoms during pregnancy. After adjustment for confounding factors, only manganese intake was independently inversely associated with depressive symptoms during pregnancy: the adjusted prevalence ratio between extreme quartiles was 0.74 (95% confidence interval:0.56-0.97, P for trend=0.046).
Information was obtained between the 5th and 39th week of pregnancy.
The current cross-sectional study of Japanese women demonstrated higher manganese intake to be independently associated with a lower prevalence of depressive symptoms during pregnancy.
加拿大的一项流行病学研究探讨了孕期锌摄入量与抑郁症状之间的关联，而韩国的另一项流行病学研究则考察了孕期铁摄入量与抑郁症状之间的关联。日本目前的这项横断面研究调查了孕期锌、镁、铁、铜和锰的摄入量与抑郁症状之间的关联。
研究对象为1745名孕妇。使用自行填写的饮食史问卷评估前一个月的饮食摄入量。抑郁症状定义为在流行病学研究中心抑郁量表上的得分≥16分。对年龄、孕周、居住地区、子女数量、家庭结构、抑郁病史、抑郁家族史、吸烟、在家和工作场所接触二手烟、就业情况、家庭收入、教育程度、体重指数以及饱和脂肪酸、二十碳五烯酸加二十二碳六烯酸、钙、维生素D和异黄酮的摄入量进行了调整。
在粗分析中，观察到锌、镁、铁、铜和锰的摄入量水平与孕期抑郁症状的患病率之间存在显著的负相关。在对混杂因素进行调整后，只有锰的摄入量与孕期抑郁症状独立呈负相关：极端四分位数之间的调整患病率比为0.74（95%置信区间：0.56 - 0.97，趋势检验P = 0.046）。
信息是在怀孕第5周到第39周期间获得的。
目前对日本女性的横断面研究表明，孕期锰摄入量较高与抑郁症状患病率较低独立相关。
