Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; Department of Life Science, Chinese Culture University, Taipei, Taiwan.
Atherosclerosis. 2017 Feb;257:71-77. doi: 10.1016/j.atherosclerosis.2016.12.020. Epub 2016 Dec 18.
There are many IL1RL1 single nucleotide polymorphisms (SNP) significantly associated with circulating sST2 concentration. Little is known about the effects of IL1RL1 SNP on the outcome of cardiovascular disease. The aim of this study is to investigate whether IL1RL1 SNP can predict mortality.
We enrolled 601 individuals receiving health examination, 532 patients with coronary artery disease (CAD), and 86 patients with peripheral artery disease (PAD). Genotyping for SNP rs950880 and rs13001325 was performed and sST2 level was measured. The primary endpoint was all-cause death. The secondary endpoints were cardiovascular death, myocardial infarction, hospitalization for heart failure, stroke, and amputation.
Individuals having rs950880 AA genotype all had rs13001325 TT genotype and tended to have lower sST2 levels in all 3 populations. Kaplan-Meier survival curves showed that patients with high sST2 level and rs950880 AA genotype had the lowest survival rate in presence of CAD (p < 0.001) and PAD (p = 0.007). In multivariable Cox regression analysis, the independent predictors of all-cause death were rs950880 AA homozygote (p = 0.018), age (p = 0.002), log sST2 level (p = 0.014), and log GDF-15 level (p = 0.017) in CAD patients. The independent predictor of all-cause death was rs950880-AA homozygote (p = 0.019) in PAD patients. There was no significant difference in secondary endpoints between rs950880 AA homozygote and C allele carriers.
Individuals having rs950880 AA genotype also have rs13001325 TT genotype and tend to have lower sST2 levels. The rs950880 AA homozygote is an independent predictor of all-cause mortality in CAD and PAD patients.
有许多 IL1RL1 单核苷酸多态性（SNP）与循环 sST2 浓度显著相关。关于 IL1RL1 SNP 对心血管疾病结局的影响知之甚少。本研究旨在探讨 IL1RL1 SNP 是否可预测死亡率。
我们纳入了 601 名接受健康检查的个体、532 名冠心病（CAD）患者和 86 名外周动脉疾病（PAD）患者。对 SNP rs950880 和 rs13001325 进行基因分型，并测量 sST2 水平。主要终点为全因死亡。次要终点为心血管死亡、心肌梗死、心力衰竭住院、卒中和截肢。
所有 3 个人群中，rs950880 AA 基因型个体均为 rs13001325 TT 基因型，且 sST2 水平较低。Kaplan-Meier 生存曲线显示，CAD（p<0.001）和 PAD（p=0.007）患者中 sST2 水平较高且 rs950880 AA 基因型的患者生存率最低。多变量 Cox 回归分析显示，CAD 患者全因死亡的独立预测因子为 rs950880 AA 纯合子（p=0.018）、年龄（p=0.002）、log sST2 水平（p=0.014）和 log GDF-15 水平（p=0.017）。PAD 患者全因死亡的独立预测因子为 rs950880-AA 纯合子（p=0.019）。rs950880 AA 纯合子与 C 等位基因携带者在次要终点方面无显著差异。
rs950880 AA 基因型个体也为 rs13001325 TT 基因型，且 sST2 水平较低。rs950880 AA 纯合子是 CAD 和 PAD 患者全因死亡率的独立预测因子。
