Department of Internal Medicine, Cardiovascular Center & Divisionof Cardiology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
Biomark Med. 2019 Jun;13(9):751-760. doi: 10.2217/bmm-2018-0458. Epub 2019 Jun 3.
This study aims to investigate whether osteoprotegerin (OPG) or osteopontin (OPN) single nucleotide polymorphisms (SNPs) will predict survival. This study enrolled 617 participants undergoing health examination, 536 coronary artery disease (CAD) patients and 86 peripheral artery disease (PAD) patients. Genotypes of SNP rs2073618 and SNP rs11730582 were determined. OPG and OPN levels were measured. In both CAD and PAD populations, high OPG and OPN levels were strong predictors of all-cause death. The rs2073618 CC genotype and the rs11730582 TT genotype did not predict mortality. High OPG and high OPN levels, but not rs2073618 CC genotype or rs11730582 TT genotype, were strong predictors of mortality in both CAD and PAD patients.
本研究旨在探讨骨保护素 (OPG) 或骨桥蛋白 (OPN) 单核苷酸多态性 (SNP) 是否可预测生存。本研究纳入 617 名接受健康检查的参与者，536 名冠心病 (CAD) 患者和 86 名外周动脉疾病 (PAD) 患者。确定了 SNP rs2073618 和 SNP rs11730582 的基因型。测量了 OPG 和 OPN 水平。在 CAD 和 PAD 人群中，高 OPG 和 OPN 水平是全因死亡的强预测因子。rs2073618 CC 基因型和 rs11730582 TT 基因型不能预测死亡率。高 OPG 和高 OPN 水平，但不是 rs2073618 CC 基因型或 rs11730582 TT 基因型，是 CAD 和 PAD 患者死亡的强预测因子。
