水热合成聚乙烯亚胺保护的高发光 Pt 纳米簇及其在硝基咪唑类化合物检测中的应用。
Hydrothermal synthesis of polyethylenimine-protected high luminescent Pt-nanoclusters and their application to the detection of nitroimidazoles.
机构信息
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China; College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin, 132022, China.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.
出版信息
Anal Chim Acta. 2017 Mar 15;958:51-58. doi: 10.1016/j.aca.2016.12.033. Epub 2016 Dec 28.
A novel one-step hydrothermal synthesis of highly fluorescent platinum nanoclusters protected by polyethylenimine (Pt-NCs@PEI) is described. The products are characterized well by UV-vis absorption, fluorescence spectra, X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM) imaging. The Pt-NCs@PEI possess high quantum yield at 28%, which is the relatively high one among the reported Pt-NCs; especially, the synthesis is in one-step and the reaction time is much shorter (<1 h) than the related methods. In addition, the Pt-NCs@PEI have large Stocks-shift (∼150 nm), high tolerability to the extreme pH and high ionic strengths, and excellent photo-stability under UV-vis irradiation, lay the foundation for the practical bio-applications. Finally, the obtained Pt-NCs@PEI are used to determine trace amount of metronidazole (MTZ) in buffer solution in showing a linear response over a concentration range of 0.25-300 μM and a low detection limit of 0.1 μM. Furthermore, the related investigation on response mechanism will be helpful to design and synthesize new metal nanoclusters as fluorescent probe to detect the trace amount of harmful medicine residuum as nitroimidazoles in human body.
描述了一种新颖的一步水热合成方法，可制备由聚乙烯亚胺（PEI）保护的高荧光铂纳米簇（Pt-NCs@PEI）。通过紫外-可见吸收光谱、荧光光谱、X 射线光电子能谱（XPS）和透射电子显微镜（TEM）成像对产物进行了很好的表征。Pt-NCs@PEI 的量子产率为 28%，在已报道的 Pt-NCs 中相对较高；特别是，该合成是一步法，反应时间比相关方法短得多（<1 h）。此外，Pt-NCs@PEI 具有较大的斯托克斯位移（∼150nm）、对极端 pH 值和高离子强度的高耐受性以及在紫外-可见照射下的优异光稳定性，为实际的生物应用奠定了基础。最后，将获得的 Pt-NCs@PEI 用于测定缓冲溶液中痕量甲硝唑（MTZ），在 0.25-300 μM 的浓度范围内表现出线性响应，检测限低至 0.1 μM。此外，对响应机制的相关研究有助于设计和合成新型金属纳米簇作为荧光探针，以检测人体内痕量有害药物残留的硝基咪唑类。
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