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一种利用希尔伯特-黄变换进行充血性心力衰竭疾病早期诊断的新方法。

A new approach to early diagnosis of congestive heart failure disease by using Hilbert-Huang transform.

作者信息

Altan Gokhan, Kutlu Yakup, Allahverdi Novruz

机构信息

Mustafa Kemal University, Antakya, Turkey.

Iskenderun Technical University, İskenderun, Turkey.

出版信息

Comput Methods Programs Biomed. 2016 Dec;137:23-34. doi: 10.1016/j.cmpb.2016.09.003. Epub 2016 Sep 7.

Abstract

Congestive heart failure (CHF) is a degree of cardiac disease occurring as a result of the heart's inability to pump enough blood for the human body. In recent studies, coronary artery disease (CAD) is accepted as the most important cause of CHF. This study focuses on the diagnosis of both the CHF and the CAD. The Hilbert-Huang transform (HHT), which is effective on non-linear and non-stationary signals, is used to extract the features from R-R intervals obtained from the raw electrocardiogram data. The statistical features are extracted from instinct mode functions that are obtained applying the HHT to R-R intervals. Classification performance is examined with extracted statistical features using a multilayer perceptron neural network. The designed model classified the CHF, the CAD patients and a normal control group with rates of 97.83%, 93.79% and 100%, accuracy, specificity and sensitivity, respectively. Also, early diagnosis of the CHF was performed by interpretation of the CAD with a classification accuracy rate of 97.53%, specificity of 98.18% and sensitivity of 97.13%. As a result, a single system having the ability of both diagnosis and early diagnosis of CHF is performed by integrating the CAD diagnosis method to the CHF diagnosis method.

摘要

充血性心力衰竭(CHF)是一种心脏疾病,由于心脏无法为人体泵出足够的血液而发生。在最近的研究中,冠状动脉疾病(CAD)被认为是CHF的最重要原因。本研究重点关注CHF和CAD的诊断。希尔伯特-黄变换(HHT)对非线性和非平稳信号有效,用于从原始心电图数据获得的R-R间期提取特征。统计特征从应用HHT于R-R间期获得的本征模函数中提取。使用多层感知器神经网络,通过提取的统计特征检验分类性能。所设计的模型分别以97.83%、93.79%和100%的准确率、特异性和敏感性对CHF患者、CAD患者和正常对照组进行了分类。此外,通过对CAD的解读对CHF进行早期诊断,分类准确率为97.53%,特异性为98.18%,敏感性为97.13%。结果,通过将CAD诊断方法集成到CHF诊断方法中,实现了一个具有CHF诊断和早期诊断能力的单一系统。

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