Osborn Scott R, Yu Julianna, Williams Barbara, Vasilyadis Maria, Blackmore C Craig
Virginia Mason Medical Center, Seattle, Washington.
J Emerg Med. 2017 Apr;52(4):538-546. doi: 10.1016/j.jemermed.2016.07.120. Epub 2017 Jan 19.
Prescription opioid-associated abuse and overdose is a significant cause of morbidity and mortality in the United States. Opioid prescriptions generated from emergency departments (EDs) nationwide have increased dramatically over the past 20 years, and opioid-related overdose deaths have become an epidemic, according to the Centers for Disease Control and Prevention.
Our aim was to determine the effectiveness of implementing a prescription policy for opioids on overall opioid prescribing patterns in a hospital ED.
The ED provider group of an academic, non-university-affiliated urban hospital with 23,000 annual patient visits agreed to opioid prescribing guidelines for chronic pain with the goal of limiting prescriptions that may be used for abuse or diversion. These guidelines were instituted in the ED through collaborative staff meetings and educational and training sessions. We used the electronic medical record to analyze the number and type of opioid discharge prescriptions during the study period from 2006-2014, before and after the prescribing guidelines were instituted in the ED.
The number of patients discharged with a prescription for opioids decreased 39.6% (25.7% to 15.6%; absolute decrease 10.2%; 95% confidence interval [CI] 9.6-10.7; p < 0.001) after the intervention. The improvements were sustained 2.5 years after the intervention. Decreases were seen in all major opioids (hydrocodone, oxycodone, hydromorphone, and codeine). The number of pills per prescription also decreased 14.8%, from 19.5% to 16.6% (absolute decrease 2.9; 95% CI 2.6-3.1; p < 0.001).
Implementation of an ED prescription opioid policy was associated with a significant reduction in total opioid prescriptions and in the number of pills per prescription.
在美国,处方阿片类药物相关的滥用和过量使用是发病和死亡的重要原因。根据疾病控制与预防中心的数据,在过去20年里,全国急诊科开具的阿片类药物处方急剧增加,与阿片类药物相关的过量死亡已成为一种流行病。
我们的目的是确定在医院急诊科实施阿片类药物处方政策对总体阿片类药物处方模式的有效性。
一家每年有23000例患者就诊的学术性、非大学附属城市医院的急诊科医疗服务人员小组同意了慢性疼痛的阿片类药物处方指南,目标是限制可能被用于滥用或转移用途的处方。这些指南通过工作人员协作会议以及教育和培训课程在急诊科实施。我们利用电子病历分析了2006年至2014年研究期间,即急诊科实施处方指南前后,阿片类药物出院处方的数量和类型。
干预后,开具阿片类药物处方出院的患者数量减少了39.6%(从25.7%降至15.6%;绝对降幅为10.2%;95%置信区间[CI]为9.6 - 10.7;p < 0.001)。干预后2.5年,这种改善仍持续存在。所有主要阿片类药物(氢可酮、羟考酮、氢吗啡酮和可待因)的使用量均有所下降。每张处方的药丸数量也减少了14.8%,从19.5降至16.6(绝对降幅为2.9;95% CI为2.6 - 3.1;p < 0.001)。
急诊科阿片类药物处方政策的实施与阿片类药物处方总量及每张处方药丸数量的显著减少相关。