Guzel Saime, Yibar Artun, Belenli Deniz, Cetin Ismail, Tanriverdi Meltem
Department of Biochemistry, Faculty of Veterinary Medicine, University of Uludag, 16059, Bursa, Gorukle, Turkey.
J Vet Med Sci. 2017 Mar 23;79(3):602-607. doi: 10.1292/jvms.16-0061. Epub 2017 Jan 21.
The main objectives of our study were to measure the major adipokines adiponectin, leptin and resistin in goat milk, to assess their interrelationships and to assess their relationships with the plasma and serum concentrations of total protein, cholesterol, total lipids, plasma C-reactive protein (CRP), milk somatic cell count (SCC), milk total aerobic colony and lactobacillus count, and milk components in lactating Saanen goats. The study was performed on eighteen lactating Saanen goats. Milk and blood samples were collected on days 20, 35, 50, 65 and 80 of lactation postpartum. The milk and plasma adiponectin levels on days 50, 65 and 80 postpartum were significantly higher than those on day 20. The milk and plasma leptin levels were lower on day 20 than on days 35, 50, 65 and 80. The milk concentrations of these major adipokines were positively intercorrelated. The milk and plasma concentrations of these three adipokines were also positively correlated. The plasma CRP concentrations correlated positively with milk leptin and resistin concentrations and inversely with milk adiponectin concentration. Milk adiponectin concentration was inversely related with its SCC. These data confirm that adiponectin, leptin and resistin are present in goat milk. The milk concentrations of these three adipokines were interrelated and interacted with the general inflammatory marker, CRP. The inverse relationship between milk adiponectin concentrations and its SCC suggests that variations in milk adiponectin might be involved in the udder health of lactating goats, but clinical trials are needed to support this hypothesis.
我们研究的主要目的是测定山羊奶中主要的脂肪因子脂联素、瘦素和抵抗素，评估它们之间的相互关系，以及评估它们与泌乳萨能山羊血浆和血清中总蛋白、胆固醇、总脂质、血浆C反应蛋白（CRP）、牛奶体细胞计数（SCC）、牛奶总需氧菌落数和乳酸菌计数以及牛奶成分之间的关系。该研究对18只泌乳萨能山羊进行。在产后泌乳的第20、35、50、65和80天采集牛奶和血液样本。产后第50、65和80天的牛奶和血浆脂联素水平显著高于第20天。第20天的牛奶和血浆瘦素水平低于第35、50、65和80天。这些主要脂肪因子的牛奶浓度呈正相关。这三种脂肪因子的牛奶和血浆浓度也呈正相关。血浆CRP浓度与牛奶瘦素和抵抗素浓度呈正相关，与牛奶脂联素浓度呈负相关。牛奶脂联素浓度与其SCC呈负相关。这些数据证实脂联素、瘦素和抵抗素存在于山羊奶中。这三种脂肪因子的牛奶浓度相互关联，并与一般炎症标志物CRP相互作用。牛奶脂联素浓度与其SCC之间的负相关表明，牛奶脂联素的变化可能与泌乳山羊的乳房健康有关，但需要临床试验来支持这一假设。
