Oh Hannah, Eliassen A Heather, Wang Molin, Smith-Warner Stephanie A, Beck Andrew H, Schnitt Stuart J, Collins Laura C, Connolly James L, Montaser-Kouhsari Laleh, Polyak Kornelia, Tamimi Rulla M
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
NPJ Breast Cancer. 2016;2:16032-. doi: 10.1038/npjbcancer.2016.32. Epub 2016 Oct 26.
Although expression of estrogen receptor (ER), progesterone receptor (PR), and cell proliferation marker Ki67 serve as predictive and prognostic factors in breast cancers, little is known about their roles in normal breast tissue. Here in a nested case-control study within the Nurses' Health Studies (90 cases, 297 controls), we evaluated their expression levels in normal breast epithelium in relation to subsequent breast cancer risk among women with benign breast disease. Tissue microarrays were constructed using cores obtained from benign biopsies containing normal terminal duct lobular units and immunohistochemical stained for these markers. We found PR and Ki67 expression was non-significantly but positively associated with subsequent breast cancer risk, whereas ER expression was non-significantly inversely associated. After stratifying by lesion subtype, Ki67 was significantly associated with higher risk among women with proliferative lesions with atypical hyperplasia. However, given the small sample size, further studies are required to confirm these results.
尽管雌激素受体（ER）、孕激素受体（PR）的表达以及细胞增殖标志物Ki67在乳腺癌中可作为预测和预后因素，但它们在正常乳腺组织中的作用却鲜为人知。在护士健康研究中的一项巢式病例对照研究中（90例病例，297例对照），我们评估了良性乳腺疾病女性正常乳腺上皮中这些标志物的表达水平与后续患乳腺癌风险的关系。使用从包含正常终末导管小叶单位的良性活检组织中获取的组织芯构建组织微阵列，并对这些标志物进行免疫组织化学染色。我们发现PR和Ki67的表达与后续患乳腺癌风险呈非显著但正相关，而ER的表达呈非显著负相关。按病变亚型分层后，Ki67与伴有非典型增生的增殖性病变女性的较高风险显著相关。然而，鉴于样本量较小，需要进一步研究来证实这些结果。
