Güngör İpek, Çakar Arman, Kocasoy Orhan Elif, Baykan Betül
Department of Neurology, Istanbul Faculty of Medicine, Istanbul, Turkey.
Agri. 2016 Oct;28(4):199-202. doi: 10.5505/agri.2015.47123.
The syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL), is a rare, benign, self-limiting syndrome that is not well known. Cerebrospinal fluid examination (CSF) on clinical suspicion has diagnostic value for this syndrome, which has a rich neurological symptomatology that can mimic many diseases causing mortality and morbidity. Although the ethiopathogenesis of this syndrome is not fully known, autoimmunity is thought to be in the foreground. Described in this article is a HaNDL case that on first clinic presentation appeared to be a transient ischemic attack (TIA) with temporary but recurring neurological findings and normal CSF pressure accompanied by papilledema. Clinical features, epidemiology, ethiopathogenesis, differential diagnosis, and treatment of this syndrome are reviewed according to the literature.
伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）是一种罕见、良性、自限性综合征，目前尚不为人熟知。临床怀疑时进行脑脊液检查（CSF）对该综合征具有诊断价值，其具有丰富的神经系统症状，可模仿许多导致死亡和发病的疾病。尽管该综合征的病因发病机制尚未完全明确，但自身免疫被认为起主要作用。本文描述了一例HaNDL病例，首次临床就诊时表现为短暂性脑缺血发作（TIA），伴有暂时但反复出现的神经学表现、正常脑脊液压力及视乳头水肿。根据文献对该综合征的临床特征、流行病学、病因发病机制、鉴别诊断及治疗进行了综述。
