Çoban Arzu, Shugaiv Erkingül, Tüzün Erdem
İstanbul University Istanbul Medical Faculty, Department of Neurology, İstanbul, Turkey.
İstanbul University Experimental Research Institute (DETAE), Department of Neuroscience, İstanbul, Turkey.
Noro Psikiyatr Ars. 2013 Aug;50(Suppl 1):S52-S55. doi: 10.4274/npa.y7228. Epub 2013 Aug 1.
The syndrome of headache accompanied with transient neurologic deficits and cerebrospinal fluid lymphocytosis (HaNDL), is a rare, benign and self limiting syndrome. In the 2nd Edition of the International Classification of Headache Disorders, HaNDL syndrome was defined in secondary headache group as "Headache attributed to non-vascular intracranial disorder". The etiology of HaNDL is still unknown. In recent years, some authors have shown that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis. In this paper, the definition of HaNDL syndrome, clinical picture and epidemiology of HaNDL syndrome, etiopathogenesis, differential diagnosis and treatment will be reviewed with the recent literature.
伴有短暂性神经功能缺损和脑脊液淋巴细胞增多的头痛综合征（HaNDL）是一种罕见的、良性的、自限性综合征。在《国际头痛疾病分类》第2版中，HaNDL综合征在继发性头痛组中被定义为“归因于非血管性颅内疾病的头痛”。HaNDL的病因仍不清楚。近年来，一些作者表明离子通道自身免疫可能至少部分促成了HaNDL的发病机制。本文将结合近期文献对HaNDL综合征的定义、临床表现、流行病学、病因发病机制、鉴别诊断及治疗进行综述。
