Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871, China.
Department of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA.
Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2376-2380. doi: 10.1002/anie.201611642. Epub 2017 Jan 23.
A site-selective rhodium-catalyzed C-C activation of ring-fused cyclopentanones was achieved to afford efficient access to a range of spiroindanones. The use of bulky 2-amino-6-picoline as a cocatalyst is key to the excellent selectivity of this C-C bond cleavage in cyclopentanones.
通过环合环戊酮的铑催化的位点选择性 C-C 活化反应，实现了高效合成一系列螺吲哚酮的方法。使用大位阻的 2-氨基-6-吡啶作为共催化剂是该 C-C 键在环戊酮中断裂具有优异选择性的关键。
