Solanki R L, Arora H L, Anand V K, Gaur S K, Gupta R
Indian J Dermatol Venereol Leprol. 1989 Jan-Feb;55(1):38-43.
The present paper deals with a clinico-pathological analysis of 172 cases of basal cell epithelioma representing 28% of the total skin cancer case. 1.44% of the total malignant tumours, 1% of the total tumours and 0.24% of the hospital admissions. M:F ratio was 1.26:1. The mean age was 54.06 years with the maximum number of cases in the fifth decade., Most (94%) of the lesions were seen on the head and neck region. Histopathologically it showed solid (60.5%), adenoid cystic (15,7%), keratotic (9.3%), pigmented (6.4%), basi-squamous (3.5%) and morphoea patterns (2.3%). Perineural lymphatic invasion was seen in 52% of the adenoid cystic basal call epithelioma. Amyloid (12.8%) and amyloid like deposits (29.65%) were seen in 42% of the case. Amyloid deposits were seen as lichen amyloidosis in 10.46% cases and in or around the tumour cell masses in 16.8% cases. It appeared as structureless homogeneous eosinophilic material and showed congophilia with apple green birefringence on polarising microscopy. It was found to be KMN04 sensitive (AA type protein- secondary amyloidosis). Amyloid like deposits appeared as less homogeneous,, basophilic, fractured material which showed non-specific congophilia with apple- green birefringence and stained with acid orcein stain indicating degenerated collagen (elastoid-degeneration).
本文对172例基底细胞上皮瘤进行了临床病理分析，这些病例占皮肤癌病例总数的28%，占全部恶性肿瘤的1.44%，占全部肿瘤的1%，占医院住院病例的0.24%。男女比例为1.26:1。平均年龄为54.06岁，发病最多的年龄段为第五个十年。大多数（94%）病变见于头颈部区域。组织病理学显示，实性型（60.5%）、腺样囊性型（15.7%）、角化型（9.3%）、色素沉着型（6.4%）、基底鳞状型（3.5%）和硬斑病样型（2.3%）。52%的腺样囊性基底细胞上皮瘤可见神经周围淋巴浸润。42%的病例可见淀粉样物质（12.8%）和淀粉样物质样沉积物（29.65%）。10.46%的病例中淀粉样物质沉积物表现为苔藓样淀粉样变，16.8%的病例中见于肿瘤细胞团块内或其周围。其表现为无结构的均匀嗜酸性物质，在偏振显微镜下呈苹果绿双折射阳性，对高锰酸钾敏感（AA型蛋白 - 继发性淀粉样变）。淀粉样物质样沉积物表现为不太均匀的嗜碱性、破碎物质，呈苹果绿双折射阳性的非特异性嗜刚果红反应，用酸性orcein染色显示为变性胶原（弹性样变性）。
