Kim I S, Amanchenko V G, Kuznetsov S V, Strizhova N V, Malashenkova I K, Alizade I G
Klin Med (Mosk). 1989 Jul;67(7):40-3.
The paper presents a discussion on therapeutic results obtained with plasmapheresis treatment in 16 patients with stage II essential hypertension. Thirty-three comparable patients entered a control group of conventional treatment. The test and control patients with stage II hypertension were examined for time-course changes in T- and B-lymphocytes counts, the activity of the energetic enzymes (alpha-glycerophosphate dehydrogenase, succinic dehydrogenase, lactate dehydrogenase), serum immunoglobulins and circulating immune complex levels. It was established that the standard antihypertensive treatment failed to restore normal parameters of immunity and to favor positive alterations in the activity of the enzymes in the blood lymphocytes, whereas therapeutic plasmapheresis was found to stimulate immunity, especially cellular one. This occurred in line with a rise in the levels of lymphocytic dehydrogenases.
本文讨论了对16例II期原发性高血压患者进行血浆置换治疗的疗效。33例情况相当的患者进入常规治疗对照组。对II期高血压的试验组和对照组患者进行了T淋巴细胞和B淋巴细胞计数、能量酶（α-甘油磷酸脱氢酶、琥珀酸脱氢酶、乳酸脱氢酶）活性、血清免疫球蛋白和循环免疫复合物水平随时间变化的检查。结果发现，标准抗高血压治疗未能恢复免疫的正常参数，也未能促进血液淋巴细胞中酶活性的积极改变，而治疗性血浆置换被发现可刺激免疫，尤其是细胞免疫。这与淋巴细胞脱氢酶水平的升高一致。
