Legkonogov A V, Kukharchuk V V, Osipov S G, Kutsenko A I
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1987;10(1):25-9.
After several plasmapheresis procedures 25 out of 28 patients with high arterial hypertension revealed stable BP lowering, accompanied by elimination of their refractoriness to medical therapy. Enhanced sensitivity of lymphocytes to antihypertensive drugs has been established by lymphocyte rosette-formation with allogenic erythrocytes loaded with these preparations. Plasmapheresis was followed by moderate reduction in IgA, IgM and IgG levels with their subsequent recovery to baseline values within 3-7 days. In a number of patients with drug hypersensitivity plasmapheresis contributed to a considerable attenuation of drug-induced allergy and caused a decrease in the initially elevated IgE level. Possible mechanisms of eliminating refractoriness to medical therapy by plasmapheresis are discussed.
在进行几次血浆置换术后，28例重度高血压患者中有25例血压稳定下降，同时消除了对药物治疗的抵抗性。通过淋巴细胞与负载这些制剂的同种异体红细胞形成玫瑰花结，确定淋巴细胞对抗高血压药物的敏感性增强。血浆置换后，IgA、IgM和IgG水平适度降低，随后在3 - 7天内恢复至基线值。在一些药物过敏患者中，血浆置换有助于显著减轻药物诱导的过敏反应，并使最初升高的IgE水平降低。文中讨论了血浆置换消除对药物治疗抵抗性的可能机制。
