Liu Kuan-Ting, Liu Yao-Hua, Chen Yen-Hsu, Lin Chun-Yu, Huang Chung-Hao, Yen Meng-Chi, Kuo Po-Lin
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Int J Mol Sci. 2016 May 27;17(6):832. doi: 10.3390/ijms17060832.
Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined. The aim of this study was to investigate the serum concentration and potential interaction of soluble galectin-1, galectin-3, galectin-9, galectin-3 binding protein (galectin-3BP), glycoprotein 130 (gp130), and E-, L-, and P-selectin in patients with dengue fever in acute febrile phase. In this study, 317 febrile patients (187 dengue patients, 150 non-dengue patients that included 48 patients with bacterial infection and 102 patients with other febrile illness) who presented to the emergency department and 20 healthy controls were enrolled. Our results showed the levels of galectin-9 and galectin-3BP were significantly higher in dengue patients than those in healthy controls. Lower serum levels of galectin-1, galectin-3, and E-, L-, and P-selectin in dengue patients were detected compared to bacteria-infected patients, but not to healthy controls. In addition, strong correlation between galectin-9 and galectin-3BP was observed in dengue patients. In summary, our study suggested galectin-9 and galectin-3BP might be critical inflammatory mediators in acute dengue virus infection.
登革热是对公共卫生的严重威胁，可诱导包括半乳糖凝集素和糖蛋白在内的多种炎性细胞因子和介质。在登革热病程的不同阶段会诱导不同的免疫反应和免疫途径。然而，血清半乳糖凝集素和糖蛋白的状况尚未完全明确。本研究的目的是调查急性发热期登革热患者血清中可溶性半乳糖凝集素-1、半乳糖凝集素-3、半乳糖凝集素-9、半乳糖凝集素-3结合蛋白（galectin-3BP）、糖蛋白130（gp130）以及E-、L-和P-选择素的浓度及其潜在相互作用。本研究纳入了317名到急诊科就诊的发热患者（187名登革热患者，150名非登革热患者，其中包括48名细菌感染患者和102名患有其他发热性疾病的患者）以及20名健康对照者。我们的结果显示，登革热患者血清中半乳糖凝集素-9和半乳糖凝集素-3BP的水平显著高于健康对照者。与细菌感染患者相比，登革热患者血清中半乳糖凝集素-1、半乳糖凝集素-3以及E-、L-和P-选择素的水平较低，但与健康对照者相比无差异。此外，在登革热患者中观察到半乳糖凝集素-9与半乳糖凝集素-3BP之间存在强相关性。总之，我们的研究表明半乳糖凝集素-9和半乳糖凝集素-3BP可能是急性登革病毒感染中的关键炎性介质。
