The Departments of Interventional Ultrasonics, General Hospital of Chinese PLA, Fuxing Road 28. 100853, Beijing, China.
Sci Rep. 2017 Jan 23;7:41246. doi: 10.1038/srep41246.
To confirm the safety and effectiveness of the minimally invasive thermal monitor technique on percutaneous ultrasound-guided microwave ablation (MWA) for hepatocellular carcinoma (HCC) in high-risk locations, a total of 189 patients with 226 HCC nodules in high-risk locations were treated with MWA. The real-time temperature of the tissue between the lesion margin and the vital structures was monitored by inserting a 21G thermal monitoring needle. The major indexes of technical success, technique effectiveness, local tumour progression and complications were observed during the follow-up period. Technical success was acquired in all patients. Technique effectiveness was achieved with one session in 119 lesions based on contrast-enhanced ultrasound (CEUS) 3-5 days after treatment. An additional 95 lesions achieved technique effectiveness at the second session. Within the follow-up period of 6-58 months (median 38 months), the 1-, 2-, 3-, and 4-year local tumour progression rate was 11.1%, 18.1%, 19.1%, and 19.9%, respectively. There were no major complications in all the patients except for the common side effects. These results indicate that the thermal monitor technique can be applied to prevent major complications in vulnerable structures and allow percutaneous MWA to achieve satisfactory technique effectiveness in the treatment of HCC in high-risk locations.
为了确认微创热监测技术在经皮超声引导微波消融（MWA）治疗高危部位肝细胞癌（HCC）中的安全性和有效性，共对 189 例 226 个高危部位 HCC 结节患者进行了 MWA 治疗。通过插入 21G 热监测针监测病变边缘与重要结构之间组织的实时温度。在随访期间观察主要技术成功、技术有效性、局部肿瘤进展和并发症指标。所有患者均获得技术成功。根据治疗后 3-5 天的超声造影（CEUS），119 个病灶单次治疗达到技术有效，95 个病灶行二次治疗达到技术有效。在 6-58 个月（中位 38 个月）的随访期间，1、2、3、4 年局部肿瘤进展率分别为 11.1%、18.1%、19.1%和 19.9%。所有患者均无重大并发症，仅出现常见的不良反应。这些结果表明，热监测技术可应用于预防脆弱结构的重大并发症，并允许经皮 MWA 在高危部位 HCC 的治疗中达到满意的技术有效性。
