Unit of Measurements and Biomedical Instrumentation, Centre for Integrated Research, University Campus Bio-Medico , Rome , Italy.
Int J Hyperthermia. 2013 Nov;29(7):609-19. doi: 10.3109/02656736.2013.832411. Epub 2013 Sep 13.
Laser-induced thermotherapy (LITT) is a hyperthermic procedure recently employed to treat cancer in several organs. The amount of coagulated tissue depends on the temperature distribution around the applicator, which plays a crucial role for an optimal outcome: the removal of the whole neoplastic tissue, whilst preventing damage to the surrounding healthy tissue. Although feedback concerning tissue temperature could be useful to drive the physician in the adjustment of laser settings and treatment duration, LITT is usually performed without real-time monitoring of tissue temperature. During recent decades, many thermometric techniques have been developed to be used during thermal therapies. This paper provides an overview of techniques and sensors employed for temperature measurement during tissue hyperthermia, focusing on LITT, and an investigation of their performances in this application. The paper focuses on the most promising and widespread temperature monitoring techniques, splitting them into two groups: the former includes invasive techniques based on the use of thermocouples and fibre-optic sensors; the second analyses non-invasive methods, i.e. magnetic resonance imaging-, computerised tomography- and ultrasound-based thermometry. Background information on measuring principle, medical applications, advantages and weaknesses of each method are provided and discussed.
激光诱导热疗(LITT)是一种最近用于治疗多个器官癌症的高热治疗方法。凝固组织的数量取决于热疗仪周围的温度分布,这对获得最佳效果至关重要:既要切除整个肿瘤组织,又要防止周围健康组织受损。虽然关于组织温度的反馈信息有助于指导医生调整激光设置和治疗时间,但 LITT 通常是在没有实时监测组织温度的情况下进行的。在过去几十年中,已经开发出许多用于热疗的测温技术。本文概述了用于组织热疗期间的测温技术和传感器,重点介绍了 LITT 及其在该应用中的性能评估。本文重点介绍了最有前途和广泛应用的温度监测技术,将其分为两组:前者包括基于热电偶和光纤传感器的侵入式技术;后者分析了磁共振成像、计算机断层扫描和超声测温等非侵入式方法。文中提供并讨论了每种方法的测量原理、医疗应用、优缺点等背景信息。
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