Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Int J Hyperthermia. 2013 Jun;29(4):336-45. doi: 10.3109/02656736.2013.801521.
Reliable temperature information during clinical hyperthermia and thermal ablation is essential for adequate treatment control, but conventional temperature measurements do not provide 3D temperature information. Treatment planning is a very useful tool to improve treatment quality, and substantial progress has been made over the last decade. Thermal modelling is a very important and challenging aspect of hyperthermia treatment planning. Various thermal models have been developed for this purpose, with varying complexity. Since blood perfusion is such an important factor in thermal redistribution of energy in in vivo tissue, thermal simulations are most accurately performed by modelling discrete vasculature. This review describes the progress in thermal modelling with discrete vasculature for the purpose of hyperthermia treatment planning and thermal ablation. There has been significant progress in thermal modelling with discrete vasculature. Recent developments have made real-time simulations possible, which can provide feedback during treatment for improved therapy. Future clinical application of thermal modelling with discrete vasculature in hyperthermia treatment planning is expected to further improve treatment quality.
在临床高热和热消融中，可靠的温度信息对于充分的治疗控制至关重要，但常规的温度测量无法提供 3D 温度信息。治疗计划是提高治疗质量的非常有用的工具，在过去十年中已经取得了重大进展。热建模是热疗计划的一个非常重要和具有挑战性的方面。为此目的已经开发了各种具有不同复杂性的热模型。由于血液灌注是体内组织中能量热再分布的重要因素，因此通过对离散脉管系统进行建模可以最准确地进行热模拟。本综述描述了用于高热治疗计划和热消融的离散脉管系统热建模的进展。在离散脉管系统的热建模方面已经取得了重大进展。最近的发展使得实时模拟成为可能，可以在治疗过程中提供反馈，从而改善治疗效果。预计在高热治疗计划中使用离散脉管系统的热建模的未来临床应用将进一步提高治疗质量。
