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从一种健康补充剂中分离并鉴定出一种新型二硫代卡波地那非类似物。

Isolation and characterization of a novel dithio-carbodenafil analogue from a health supplement.

作者信息

Kee Chee-Leong, Low Min-Yong, Ge Xiaowei

机构信息

Pharmaceutical Laboratory, Applied Sciences Group, Health Sciences Authority, 11 Outram Road, 169078, Singapore.

Pharmaceutical Laboratory, Applied Sciences Group, Health Sciences Authority, 11 Outram Road, 169078, Singapore.

出版信息

J Pharm Biomed Anal. 2017 Apr 15;137:132-138. doi: 10.1016/j.jpba.2017.01.010. Epub 2017 Jan 16.

DOI:10.1016/j.jpba.2017.01.010
PMID:28113089
Abstract

A novel dithio-carbodenafil compound was isolated and identified from a health supplement. The structure of the unknown compound has been characterized using LC-UV, Fourier Transform Infrared (FTIR), high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. It has been revealed as 3,5-dimethylpiperazinyl dithio-desmethylcarbodenafil as a result of two additional methyl groups on the piperazine ring.

摘要

从一种健康补充剂中分离并鉴定出一种新型二硫代卡波地那非化合物。已使用液相色谱 - 紫外光谱（LC - UV）、傅里叶变换红外光谱（FTIR）、高分辨率质谱、一维和二维核磁共振（NMR）光谱对该未知化合物的结构进行了表征。结果表明，由于哌嗪环上有两个额外的甲基，它是3,5 - 二甲基哌嗪基二硫代去甲基卡波地那非。

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