• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从一种保健品中作为掺杂物发现的新型西地那非类似物，羟基卡宾达非的分离与鉴定。

Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement.

机构信息

China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, China; NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, 1500 Zhangheng Road, Shanghai 201203, China.

NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, 1500 Zhangheng Road, Shanghai 201203, China.

出版信息

J Pharm Biomed Anal. 2020 Jun 5;185:113222. doi: 10.1016/j.jpba.2020.113222. Epub 2020 Feb 29.

DOI:10.1016/j.jpba.2020.113222
PMID:32145539
Abstract

During routine screening of illegal adulterants in health supplements, a novel sildenafil analogue was discovered, and subsequently isolated by recrystallization. Its structure was elucidated by extensive analyses of high resolution mass spectrometry (HRMS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data. The analogue was finally determined as hydroxycarbodenafil, featuring a hydroxyethyl group instead of an ethyl group on piperazine ring in comparison with carbodenafil.

摘要

在对保健品中的非法掺杂物进行常规筛查时，发现了一种新型的西地那非类似物，并通过重结晶进行了分离。通过高分辨率质谱（HRMS）、一维（1D）和二维（2D）核磁共振（NMR）数据分析，对其结构进行了广泛解析。最终将该类似物确定为羟基卡宾达非，与卡宾达非相比，其哌嗪环上的乙基被羟乙基取代。

相似文献

1
Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement.从一种保健品中作为掺杂物发现的新型西地那非类似物，羟基卡宾达非的分离与鉴定。
J Pharm Biomed Anal. 2020 Jun 5;185:113222. doi: 10.1016/j.jpba.2020.113222. Epub 2020 Feb 29.
2
Identification of a new sildenafil analogue adulterant, desethylcarbodenafil, in a herbal supplement.在一种草本补充剂中鉴定出一种新的西地那非类似物掺杂物——去乙基卡波地那非。
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Nov;33(11):1637-1642. doi: 10.1080/19440049.2016.1236402. Epub 2016 Oct 11.
3
Isolation and characterisation of a novel sildenafil analogue adulterant, desmethylpiperazinyl propoxysildenafil, in a dietary supplement.膳食补充剂中一种新型西地那非类似物掺假物——去甲基哌嗪基丙氧基西地那非的分离与表征
Sci Justice. 2018 Nov;58(6):447-454. doi: 10.1016/j.scijus.2018.07.003. Epub 2018 Jul 17.
4
Isolation and identification of a novel sildenafil analogue adulterant in herbal products.草药产品中一种新型西地那非类似物掺假物的分离与鉴定。
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Mar;34(3):330-334. doi: 10.1080/19440049.2016.1272137. Epub 2016 Dec 23.
5
Identification of a new sildenafil analogue in a health supplement.在一种保健品中鉴定出一种新型西地那非类似物。
J Pharm Biomed Anal. 2011 Nov 1;56(3):491-6. doi: 10.1016/j.jpba.2011.06.004. Epub 2011 Jun 15.
6
Identification of a novel sildenafil analogue in an adulterated herbal supplement.鉴定一种掺假草药补充剂中的新型西地那非类似物。
J Pharm Biomed Anal. 2012 Feb 5;59:58-66. doi: 10.1016/j.jpba.2011.10.001. Epub 2011 Oct 7.
7
Identification and structural elucidation of a new sildenafil analogue, dithiopropylcarbodenafil, from a premixed powder intended as a dietary supplement.从一种用作膳食补充剂的预混粉末中鉴定并阐明一种新型西地那非类似物二硫代丙基卡波地那非的结构。
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:273-281. doi: 10.1016/j.jchromb.2017.11.029. Epub 2017 Nov 24.
8
Identification of a new tadalafil analogue, N-3-hydroxypropylnortadalafil, in a supplement product.鉴定一种新的他达那非类似物，N-3-羟基丙基去甲他达那非，存在于一种补充剂产品中。
J Pharm Biomed Anal. 2018 Sep 5;158:257-261. doi: 10.1016/j.jpba.2018.05.049. Epub 2018 Jun 1.
9
Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges.筛查合成 PDE-5 抑制剂及其类似物作为掺杂物：分析技术和挑战。
J Pharm Biomed Anal. 2014 Jan;87:176-90. doi: 10.1016/j.jpba.2013.04.037. Epub 2013 May 6.
10
[Identification of a new sildenafil analogue based on Q-TOF-MS].[基于Q-TOF-MS鉴定一种新型西地那非类似物]
Yao Xue Xue Bao. 2014 Apr;49(4):513-6.

引用本文的文献

1
[Liquid chromatography-high resolution mass spectrometry analysis of 300 illegally added drugs and their analogues in functional milk powder for the elderly].[老年功能性奶粉中300种非法添加药物及其类似物的液相色谱-高分辨率质谱分析]
Se Pu. 2023 Nov;41(11):960-975. doi: 10.3724/SP.J.1123.2023.05013.
2
A novel vardenafil analog in a healthcare product: Preparation, characterization, and quantification.一种保健产品中的新型伐地那非类似物：制备、表征及定量分析。
Heliyon. 2023 Aug 28;9(9):e19456. doi: 10.1016/j.heliyon.2023.e19456. eCollection 2023 Sep.
3
A multi-analyte screening method for the rapid detection of illicit adulterants in dietary supplements using a portable SERS analyzer.
一种使用便携式表面增强拉曼光谱分析仪快速检测膳食补充剂中非法掺假物的多分析物筛查方法。
Heliyon. 2023 Jul 20;9(8):e18509. doi: 10.1016/j.heliyon.2023.e18509. eCollection 2023 Aug.
4
Using a quantum dot bead-based lateral flow immunoassay to broadly detect the adulteration of PDE-5 inhibitors in functional foods.采用量子点微球侧向流免疫层析法广泛检测功能性食品中 PDE-5 抑制剂的掺假。
Anal Methods. 2022 Jul 7;14(26):2586-2595. doi: 10.1039/d2ay00580h.