The cost of departure from optimal radii in microvascular networks.

In the Murray optimality model of branching vasculatures, the radii of vessels are related to blood viscosity, vascular metabolic rate, and blood flow rate, in such a way as to minimize the total work (hydraulic and metabolic) of the system. The model predicts that flow is proportional to the cube of a vessel radius, and that at junctions the cube of the radius of the parent vessel equals the sum of the cubes of the daughter radii. In comparing real vasculatures to the Murray model, we have previously had no expressions for evaluating the apparent energy cost for departures from the optimal junction exponent of 3. Such expressions are derived here. They show that junction exponents, from about 1.5 to large positive values, are within 5% of the energy minimum. With the new equations, observed individual junctions or entire vascular trees can be compared, energy-wise, with the Murray optimum. Junctions in the transverse arteriolar trees of cat sartorius muscle were compared to the Murray optimality model, using these new expressions. The junction exponents for these small pre-capillary vessels had a broad range, with a median value greater than the Murray optimum of 3. The exponents were restricted, however, to values requiring, at individual junctions, little increase in energy. The majority of junctions had energy costs less than 1% above the Murray minimum. For entire trees involving many junctions the departures from optimality averaged less than 10%. Thus, while the branching geometry for these microvascular trees deviates significantly from the Murray optimum in the direction of larger daughter to parent ratios, the departures are small in energy terms.