IEEE Trans Neural Syst Rehabil Eng. 2017 Dec;25(12):2217-2226. doi: 10.1109/TNSRE.2016.2613412. Epub 2016 Sep 26.
This paper presents a signal processing method for the electrophysiology simultaneously recorded during deep brain stimulation (DBS) as a research tool. Regarding the local field potential (LFP) signals recorded during stimulation, a novel method was proposed for removal of stimulation artifacts caused by the much stronger stimulating pulse compared to typical LFP. This artifact suppression method was tested and evaluated in an in vitro situation. The results indicate that the stimulation artifacts are well suppressed by this method. Secondly, this method was tested in vivo in Parkinson's disease (PD) patients. It was used to process the LFP signals recorded intraoperatively from PD patients to preliminarily explore the quantitative dependencies of beta band synchronization variations in the subthalamic nucleus (STNs) on the applied DBS parameters, including stimulation voltage, frequency and pulse width. The results confirm that DBS therapy can suppress excessive beta frequency activity and that the degree of attenuation increases with increasing DBS voltage within a range of 1-3 V and increasing DBS frequency within a range of 60-120 Hz. The proposed artifact suppression method provides technical support for exploring the direct effect of electrical stimulation on the brain activities.
本文提出了一种信号处理方法，用于同时记录深部脑刺激（DBS）期间的电生理学，作为一种研究工具。针对刺激期间记录的局部场电位（LFP）信号，提出了一种新的方法，用于去除与典型 LFP 相比强度大得多的刺激脉冲引起的刺激伪影。在体外情况下对该去伪影方法进行了测试和评估。结果表明，该方法能很好地抑制刺激伪影。其次，在帕金森病（PD）患者中进行了体内测试。该方法用于处理从 PD 患者术中记录的 LFP 信号，初步探索丘脑底核（STN）中β频带同步变化与应用的 DBS 参数（包括刺激电压、频率和脉冲宽度）之间的定量关系。结果证实，DBS 治疗可以抑制过度的β频带活动，并且在 1-3V 的范围内随着 DBS 电压的增加以及在 60-120Hz 的范围内随着 DBS 频率的增加，衰减程度增加。所提出的去伪影方法为探索电刺激对大脑活动的直接影响提供了技术支持。
