Bronte-Stewart Helen, Barberini Crista, Koop Mandy Miller, Hill Bruce C, Henderson Jaimie M, Wingeier Brett
Department of Neurology and Neurological Sciences, Stanford University, CA 94305-5327, USA.
Exp Neurol. 2009 Jan;215(1):20-8. doi: 10.1016/j.expneurol.2008.09.008. Epub 2008 Sep 27.
Producing accurate movements may rely on the functional independence of sensorimotor circuits within basal ganglia nuclei. In parkinsonism there is abnormal synchrony of electrical activity within these circuits that results in a loss of independence across motor channels. Local field potential (LFP) recordings reflect the summation of local electrical fields and an increase in LFP power reflects increased synchrony in local neuronal networks. We recorded LFPs from the subthalamic nucleus (STN) deep brain stimulation (DBS) lead in the operating room in 22 cases from 16 subjects with Parkinson's disease (PD) who were off medication. There was elevated LFP power at beta frequencies (13-35 Hz) at rest. The LFP spectral profile was consistent across several periods of rest that were separated by movement and/or DBS, and appeared to be a relatively stationary phenomenon. The spectral profile and frequencies of the beta-band peak(s) varied among subjects but were similar between the right and left STNs within certain individuals. These results suggest that the LFP spectrum at rest may characterize a "signature" rhythm for an individual with PD. Beta-band power was attenuated after intra-operative STN DBS (p<0.05). The attenuation lasted for 10 s after short periods (30 s) and for up to 50 s after longer periods (5 min) of DBS. The finding that longer periods of DBS attenuated beta power for a longer time suggests that there may be long-acting functional changes to networks in the STN in PD after chronic DBS.
产生精确的动作可能依赖于基底神经节核内感觉运动回路的功能独立性。在帕金森病中，这些回路内的电活动存在异常同步，导致运动通道之间丧失独立性。局部场电位（LFP）记录反映了局部电场的总和，LFP功率增加反映了局部神经元网络同步性增加。我们在手术室中，从16名帕金森病（PD）患者（未服药）的22例病例的丘脑底核（STN）深部脑刺激（DBS）电极上记录了LFP。静息时β频率（13 - 35Hz）的LFP功率升高。LFP频谱特征在由运动和/或DBS分隔的几个静息期内是一致的，并且似乎是一种相对稳定的现象。β波段峰值的频谱特征和频率在不同个体之间有所不同，但在某些个体的右侧和左侧STN之间相似。这些结果表明，静息时的LFP频谱可能是PD个体的一种“特征”节律。术中STN DBS后β波段功率减弱（p<0.05）。在短时间（30秒）的DBS后，衰减持续10秒，在长时间（5分钟）的DBS后，衰减持续长达50秒。长时间的DBS使β功率衰减更长时间的这一发现表明，慢性DBS后PD患者STN中的网络可能存在长效功能变化。
