使用Biofire Filmarray脑膜炎/脑炎检测板增强对患有脑膜炎的幼儿中B族链球菌和大肠杆菌的鉴定。
Enhanced Identification of Group B Streptococcus and Escherichia Coli in Young Infants with Meningitis Using the Biofire Filmarray Meningitis/Encephalitis Panel.
作者信息
Arora Harbir Singh, Asmar Basim I, Salimnia Hossein, Agarwal Prashant, Chawla Sanjay, Abdel-Haq Nahed
机构信息
From the *Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, Michigan; †Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan; ‡Department of Pathology, Wayne State University, Detroit, Michigan; §Detroit Medical Center University Laboratories, Detroit, Michigan; and ¶Division of Neonatal Perinatal Medicine, Children's Hospital of Michigan, Detroit, Michigan.
出版信息
Pediatr Infect Dis J. 2017 Jul;36(7):685-687. doi: 10.1097/INF.0000000000001551.
FilmArray Meningitis/Encephalitis (ME) polymerase chain reaction (PCR) panel was tested on 62 cerebrospinal fluid (CSF) samples from young infants (0-3 months) with suspected meningitis and compared with CSF cultures. Twelve CSF samples from 9 infants were positive by ME PCR panel (10 Group B Streptococcus (GBS) and 2 Escherichia coli) of which only 5 were positive by culture. The 7 CSF samples that were positive only by ME PCR panel were obtained from infants who had received prior antibiotic treatment. The ME PCR panel can be a useful tool in the rapid diagnosis of bacterial meningitis in pretreated young infants.
对62份来自疑似脑膜炎的0至3个月龄婴幼儿的脑脊液样本进行了FilmArray脑膜炎/脑炎（ME）聚合酶链反应（PCR）检测，并与脑脊液培养结果进行比较。9名婴儿的12份脑脊液样本通过ME PCR检测呈阳性（10份B族链球菌（GBS）和2份大肠杆菌），其中只有5份通过培养呈阳性。仅通过ME PCR检测呈阳性的7份脑脊液样本来自接受过抗生素治疗的婴儿。ME PCR检测可作为快速诊断接受过治疗的婴幼儿细菌性脑膜炎的有用工具。
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