Department of Biopathology and Medical Biotechnologies, Section of Anesthesia Analgesia Intensive Care and Emergency, University of Palermo, Palermo, Italy.
JAMA. 2017 Jan 17;317(3):311-312. doi: 10.1001/jama.2016.16535.
Are antifungal agents associated with lower rates of mortality and invasive fungal infections when administered before definitive diagnosis of an invasive fungal infection in critically ill patients without neutropenia?
Antifungal treatment administered prior to diagnosis of an invasive fungal infection is not associated with either higher or lower rates of all-cause mortality. Antifungal treatment in this setting is associated with lower rates of invasive fungal infections compared with placebo or no intervention in critically ill patients without neutropenia, but the quality of the evidence is low.
在没有中性粒细胞减少症的危重症患者中，在明确诊断侵袭性真菌感染之前使用抗真菌药物是否与死亡率和侵袭性真菌感染率降低相关？
在侵袭性真菌感染确诊之前使用抗真菌药物与全因死亡率的升高或降低均无关。与安慰剂或不干预相比，在没有中性粒细胞减少症的危重症患者中，该治疗方案与侵袭性真菌感染发生率降低相关，但证据质量较低。
