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降钙素原用于侵袭性念珠菌病的诊断:证据有哪些?

Procalcitonin for the diagnosis of invasive candidiasis: what is the evidence?

作者信息

Raineri Santi Maurizio, Cortegiani Andrea, Vitale Filippo, Iozzo Pasquale, Giarratano Antonino

机构信息

Department of Biopathology and Medical Biotechnologies (DIBIMED). Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico P. Giaccone, University of Palermo, Via del vespro 129, 90127 Palermo, Italy.

出版信息

J Intensive Care. 2017 Sep 25;5:58. doi: 10.1186/s40560-017-0252-x. eCollection 2017.

DOI:10.1186/s40560-017-0252-x
PMID:28975031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5613326/
Abstract

Procalcitonin is a widely used marker for the evaluation of infection and sepsis and to guide antibiotic therapy. During the last decade, several studies evaluated its role and diagnostic performance as a surrogate marker for the identification of spp. in suspected invasive candidiasis. A low serum level and a favorable negative predictive value are the main findings for procalcitonin in this setting. The aim of this report is to provide an updated brief summary of the evidence supporting the use of PCT for the management of invasive candidiasis.

摘要

降钙素原是一种广泛用于评估感染和脓毒症以及指导抗生素治疗的标志物。在过去十年中,多项研究评估了其作为疑似侵袭性念珠菌病中念珠菌属鉴定替代标志物的作用和诊断性能。在这种情况下,降钙素原的主要发现是血清水平低和阴性预测值良好。本报告的目的是提供一份最新的简要概述,以支持使用降钙素原管理侵袭性念珠菌病的证据。

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本文引用的文献

1
Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy.降钙素原:一种用于脓毒症和抗生素治疗的有前景的诊断标志物。
J Intensive Care. 2017 Aug 3;5:51. doi: 10.1186/s40560-017-0246-8. eCollection 2017.
2
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Crit Care. 2017 Jul 10;21(1):176. doi: 10.1186/s13054-017-1763-5.
3
Intensive care medicine research agenda on invasive fungal infection in critically ill patients.重症患者侵袭性真菌感染的重症监护医学研究议程。
Intensive Care Med. 2017 Sep;43(9):1225-1238. doi: 10.1007/s00134-017-4731-2. Epub 2017 Mar 2.
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