利福平增强两性霉素B对来自角膜炎患者的茄病镰刀菌种复合体和黄曲霉菌种复合体分离株的活性。
Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients.
作者信息
He Yi, Zhou Lutan, Gao Chuanwen, Han Lei, Xu Yan
机构信息
Cornea Service, Henan Eye Institute & Henan Eye Hospital, and Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Department of Optometry, Zhengzhou Railway Vocational & Technical College, Zhengzhou, Henan, China.
出版信息
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.02069-16. Print 2017 Apr.
Abstract
The activities of amphotericin B in combination with rifampin were assessed against 95 ocular fungal isolates. The interactions between amphotericin B and rifampin at 4, 8, 16, and 32 μg/ml were synergistic for 11.8%, 51.0%, 90.2%, and 94.1%, respectively, of species complex isolates and for 13.6%, 45.5%, 93.2%, and 95.5%, respectively, of species complex isolates. Antagonism was never observed for the amphotericin B-rifampin combinations.
摘要
对95株眼部真菌分离株评估了两性霉素B与利福平联合使用的活性。两性霉素B与利福平在4、8、16和32μg/ml浓度下的相互作用，对于种复合群分离株分别有11.8%、51.0%、90.2%和94.1%表现为协同作用，对于种复合群分离株分别有13.6%、45.5%、93.2%和95.5%表现为协同作用。两性霉素B与利福平组合从未观察到拮抗作用。
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