两性霉素B、5-氟胞嘧啶和利福平对6株临床分离曲霉菌的活性。
Activity of amphotericin B, 5-fluorocytosine, and rifampin against six clinical isolates of Aspergillus.
作者信息
Kitahara M, Seth V K, Medoff G, Kobayashi G S
出版信息
Antimicrob Agents Chemother. 1976 Jun;9(6):915-9. doi: 10.1128/AAC.9.6.915.
Abstract
Amphotericin B in combination with 5-fluorocytosine was synergistic against three clinical isolates of Aspergillus fumigatus and one of three clinical isolates of A. flavus. Amphotericin B in combination with rifampin was synergistic against all six clinical isolates of Aspergillus tested. The levels of 5-fluorocytosine and rifampin required for synergism were higher than clinically achievable concentrations when measurements of synergism were based on visual turbidity; but when the effects of the drugs were measured by inhibition of ribonucleic acid synthesis or dry-weight increase, much lower concentrations were effective.
摘要
两性霉素B与5-氟胞嘧啶联合使用对三株烟曲霉临床分离株及三株黄曲霉临床分离株中的一株具有协同作用。两性霉素B与利福平联合使用对所检测的所有六株曲霉临床分离株均具有协同作用。当基于视觉浊度测量协同作用时，协同所需的5-氟胞嘧啶和利福平水平高于临床可达到的浓度；但当通过抑制核糖核酸合成或干重增加来测量药物作用时，低得多的浓度就有效。
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本文引用的文献
1
Growth of the yeastlike phase of Histoplasma capsulatum in a fluid medium.荚膜组织胞浆菌酵母样相在液体培养基中的生长。
J Bacteriol. 1950 Feb;59(2):312-3. doi: 10.1128/jb.59.2.312-313.1950.
2
Treatment of disseminated mycotic infectioons. A new approach to amphotericin B therapy.播散性霉菌感染的治疗。两性霉素B治疗的新方法。
Am J Med. 1968 Sep;45(3):405-18. doi: 10.1016/0002-9343(68)90075-2.
3
Synergistic action of amphotericin B and 5-fluorocytosine against yeast-like organisms.两性霉素B与5-氟胞嘧啶对酵母样菌的协同作用。
Proc Soc Exp Biol Med. 1971 Nov;138(2):571-4. doi: 10.3181/00379727-138-35943.
4
Amphotericin B potentiation of rifampicin as an antifungal agent against the yeast phase of Histoplasma capsulatum.两性霉素B增强利福平作为抗荚膜组织胞浆菌酵母相的抗真菌剂的作用。
Science. 1972 Aug 25;177(4050):709-10. doi: 10.1126/science.177.4050.709.
5
Cure of Aspergillus ustus endocarditis on a prosthetic valve.人工瓣膜上黑曲霉心内膜炎的治愈
Arch Intern Med. 1974 Mar;133(3):486-90.
6
Effect of 5-fluorocytosine and amphotericin B on Candida albicans infection in mice.5-氟胞嘧啶和两性霉素B对小鼠白色念珠菌感染的影响。
J Infect Dis. 1974 Jul;130(1):28-31. doi: 10.1093/infdis/130.1.28.
7
Chemotherapeutic activity of 5-fluorocytosine and amphotericin B against Candida albicans in mice.5-氟胞嘧啶和两性霉素B对小鼠白色念珠菌的化疗活性。
Antimicrob Agents Chemother. 1973 Sep;4(3):306-8. doi: 10.1128/AAC.4.3.306.
8
The combined effect of 5-fluorocytosine and amphotericin B in the therapy of murine cryptococcosis.5-氟胞嘧啶与两性霉素B联合治疗小鼠隐球菌病的效果
Proc Soc Exp Biol Med. 1973 Feb;142(2):476-80. doi: 10.3181/00379727-142-37049.
9
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Proc Natl Acad Sci U S A. 1972 Jan;69(1):196-9. doi: 10.1073/pnas.69.1.196.
10
RNA metabolism during morphogenesis in Histoplasma capsulatum.荚膜组织胞浆菌形态发生过程中的RNA代谢
J Gen Microbiol. 1974 Jun;82(2):301-7. doi: 10.1099/00221287-82-2-301.
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