Yang Lin, Tian Zi-Bin, Yu Ya-Nan, Zhang Cui-Ping, Li Xiao-Yu, Mao Tao, Jing Xue, Zhao Wen-Jun, Ding Xue-Li, Yang Ruo-Ming, Zhang Shuai-Qing
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
Department of Gastroenterology, Qilu Hospital of Shandong University (Qingdao), Qingdao 266000, China.
Pathog Dis. 2017 Jan 1;75(1). doi: 10.1093/femspd/ftx006.
Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue lymphoma compared with other Helicobacter species in humans and animals. Saccharomyces boulardii has been established as an adjunct to H. pylori eradication treatment, but the effect of S. boulardii administration alone on Helicobacter infection remains unclear. Here, we found that S. boulardii administration effectively decreased the bacterial load of H. suis and inhibited the formation of lymphoid follicles in the stomach post-infection. The levels of H. suis-specific immunoglobulin A (IgA) and secretory IgA in the gastric juice and small intestinal secretions and the production of mouse β-defensin-3 in the small intestinal secretions were significantly increased by S. boulardii administration at 12 weeks after H. suis infection. In addition, feeding with S. boulardii inhibited the expression of inflammatory cytokines and lymphoid follicle formation-related factors after H. suis infection. These results suggested that S. boulardii may be useful for the prevention and treatment of Helicobacter infection-related diseases in humans.
与人类和动物中的其他幽门螺杆菌相比，猪幽门螺杆菌诱发胃黏膜相关淋巴组织淋巴瘤的倾向更大。布拉氏酵母菌已被确立为根除幽门螺杆菌治疗的辅助药物，但单独施用布拉氏酵母菌对幽门螺杆菌感染的影响仍不明确。在此，我们发现施用布拉氏酵母菌可有效降低猪幽门螺杆菌的细菌载量，并抑制感染后胃中淋巴滤泡的形成。在猪幽门螺杆菌感染12周后，施用布拉氏酵母菌可显著提高胃液和小肠分泌物中猪幽门螺杆菌特异性免疫球蛋白A（IgA）和分泌型IgA的水平，以及小肠分泌物中小鼠β-防御素-3的产生。此外，用布拉氏酵母菌喂养可抑制猪幽门螺杆菌感染后炎性细胞因子的表达和淋巴滤泡形成相关因子的表达。这些结果表明，布拉氏酵母菌可能对预防和治疗人类幽门螺杆菌感染相关疾病有用。
