Effect of Probiotic-Assisted Eradication of +/ on Intestinal Flora.

OBJECTIVE

We attempted to evaluate the effects of probiotic-assisted eradication of - ()+/ () () on the intestinal flora, inflammatory factors, and clinical outcomes.

METHODS

A total of 180 patients with +/ H were randomly divided into two groups. Group A was treated with bismuth quadruple therapy (BQT). Group B was treated with in addition to BQT. The distribution of intestinal flora, serum interleukin-8 (IL-8), IL-17, tumor necrosis factor- (TNF-) levels, recovery time of clinical symptoms, total effective rate of clinical symptoms, eradication rate, and adverse reactions were observed.

RESULTS

2 weeks after treatment, the contents of , , and in the intestinal tract of Group A decreased, while the amounts of and increased. In Group B, the contents of , , and increased, while the amounts of and did not change significantly. Moreover, the trend of this flora change was still present at 4 weeks after treatment. Compared with Group A, Group B had lower IL-8, IL-17, and TNF- levels, shorter recovery time of clinical symptoms, higher overall efficiency of clinical symptoms, and lower occurrence of adverse reactions. The eradication rate did not differ significantly between the two groups.

CONCLUSION

BQT can lead to intestinal flora disorders in +/ patients. can improve the distribution of intestinal flora, downregulate immune-inflammatory mediators, and modify clinical symptoms in patients.