Harpreet Singh, Deepak Jain, Kiran B
Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak (Haryana), India.
Reumatologia. 2016;54(6):326-329. doi: 10.5114/reum.2016.64911. Epub 2016 Dec 30.
Multiple autoimmune syndrome (MAS) is a condition characterised by three or more autoimmune disorders in a same individual. Familial, immunologic and infectious factors are implicated in the development of MAS. Here we report a case of a 32-year-old woman with co-existence of four auto-immune diseases, namely autoimmune hypothyroidism, Sjögren's syndrome, systemic lupus erythematosus (SLE) and celiac disease which leads to the final diagnosis of multiple autoimmune syndrome type 3 with celiac disease. Patients with single autoimmune disorder are at 25% risk of developing other autoimmune disorders. The present case emphasises to clinicians that there is a need for continued surveillance for the development of new autoimmune disease in predisposed patients.
多重自身免疫综合征（MAS）是一种在同一个体中以三种或更多自身免疫性疾病为特征的病症。家族性、免疫学和感染性因素与MAS的发生有关。在此，我们报告一例32岁女性，她同时患有四种自身免疫性疾病，即自身免疫性甲状腺功能减退症、干燥综合征、系统性红斑狼疮（SLE）和乳糜泻，最终诊断为伴有乳糜泻的3型多重自身免疫综合征。患有单一自身免疫性疾病的患者有25%的风险会发展为其他自身免疫性疾病。本病例向临床医生强调，有必要对易感患者中新发自身免疫性疾病的发生进行持续监测。
