Brandalise Federico, Cesaroni Valentina, Gregori Andrej, Repetti Margherita, Romano Chiara, Orrù Germano, Botta Laura, Girometta Carolina, Guglielminetti Maria Lidia, Savino Elena, Rossi Paola
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Department of Biology and Biotechnology (DBB) "L. Spallanzani", University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.
Evid Based Complement Alternat Med. 2017;2017:3864340. doi: 10.1155/2017/3864340. Epub 2017 Jan 1.
(Bull.) Pers. is a medicinal mushroom capable of inducing a large number of modulatory effects on human physiology ranging from the strengthening of the immune system to the improvement of cognitive functions. In mice, dietary supplementation with prevents the impairment of spatial short-term and visual recognition memory in an Alzheimer model. Intriguingly other neurobiological effects have recently been reported like the effect on neurite outgrowth and differentiation in PC12 cells. Until now no investigations have been conducted to assess the impact of this dietary supplementation on brain function in healthy subjects. Therefore, we have faced the problem by considering the effect on cognitive skills and on hippocampal neurotransmission in wild-type mice. In wild-type mice the oral supplementation with induces, in behaviour test, a significant improvement in the recognition memory and, in hippocampal slices, an increase in spontaneous and evoked excitatory synaptic current in mossy fiber-CA3 synapse. In conclusion, we have produced a series of findings in support of the concept that induces a boost effect onto neuronal functions also in nonpathological conditions.
（牛肝菌）Pers. 是一种药用蘑菇，能够对人体生理产生大量调节作用，范围从增强免疫系统到改善认知功能。在小鼠中，在阿尔茨海默病模型中饮食补充（该蘑菇）可防止空间短期和视觉识别记忆受损。有趣的是，最近还报道了其他神经生物学效应，如对PC12细胞中神经突生长和分化的影响。到目前为止，尚未进行任何研究来评估这种饮食补充对健康受试者脑功能的影响。因此，我们通过考虑对野生型小鼠认知技能和海马神经传递的影响来面对这个问题。在野生型小鼠中，口服补充（该蘑菇）在行为测试中可显著改善识别记忆，在海马切片中可增加苔藓纤维-CA3突触的自发和诱发兴奋性突触电流。总之，我们已经得出了一系列研究结果，支持了（该蘑菇）在非病理条件下也能对神经元功能产生促进作用这一概念。
