Pålsson Mathias, Stjerndahl Jan-Henrik, Granåsen Gabriel, Löfgren Mats, Sundfeldt Karin
Department of Obstetrics and Gynaecology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden.
Int Urogynecol J. 2017 Sep;28(9):1341-1349. doi: 10.1007/s00192-017-3268-9. Epub 2017 Jan 23.
Hysterectomy is sometimes considered the cause of lower urinary tract symptoms (LUTS). We hypothesized that hysterectomy for abnormal uterine bleeding and/or symptoms of fibroids is more likely to cause LUTS than a hysteroscopic procedure for the same indications.
Two groups of women were compared: one group comprised 3,618 women who had had a hysterectomy due to abnormal uterine bleeding or symptoms of fibroids and the other group comprised 238 women who had had hysteroscopic treatment for the same indications. The main outcome measures were occurrence of LUTS before and 1 year after the surgical intervention. The frequencies of LUTS before and after surgery were compared between the groups. Binary logistic regression was used to model the odds of having postoperative urinary leakage and urgency while controlling for uterine size, surgical procedure and preoperative LUTS.
There were no statistically significant differences between women after hysterectomy and after hysteroscopy in the frequencies of LUTS before or after surgery, when uterine size was comparable. However, there was a difference in the rates of de novo urinary incontinence between women with hysterectomy and women with hysteroscopy (7.6%, 95% CI 6.3-9.0, and 3.2%, 95% CI 1.6-6.5, respectively). Of the women with a large uterus, 58.6% (95% CI 51.5-65.5) reported relief of urinary incontinence and 85.5% (95% CI 82.3-88.4) reported relief of urinary urgency postoperatively.
Our results suggest that it is important to individualize preoperative information in women prior to hysterectomy since the outcome concerning LUTS depends on preoperative symptoms and uterine size.
子宫切除术有时被认为是下尿路症状(LUTS)的病因。我们假设,因异常子宫出血和/或肌瘤症状而进行的子宫切除术比针对相同适应症的宫腔镜手术更有可能导致LUTS。
对两组女性进行比较:一组包括3618名因异常子宫出血或肌瘤症状而接受子宫切除术的女性,另一组包括238名因相同适应症接受宫腔镜治疗的女性。主要观察指标为手术干预前及术后1年LUTS的发生情况。比较两组手术前后LUTS的发生频率。采用二元逻辑回归对术后尿失禁和尿急的几率进行建模,同时控制子宫大小、手术方式和术前LUTS。
当子宫大小可比时,子宫切除术后和宫腔镜检查术后女性在手术前后LUTS发生频率上无统计学显著差异。然而,子宫切除术后女性与宫腔镜检查术后女性的新发尿失禁发生率存在差异(分别为7.6%,95%CI 6.3 - 9.0和3.2%,95%CI 1.6 - 6.5)。子宫较大的女性中,58.6%(95%CI 51.5 - 65.5)报告术后尿失禁缓解,85.5%(95%CI 82.3 - 88.4)报告术后尿急缓解。
我们的结果表明,子宫切除术前对女性进行个体化的术前信息告知很重要,因为LUTS的结果取决于术前症状和子宫大小。