Gorbach S L, Schaefer E J, Woods M, Longcope C, Dwyer J T, Goldin B R, Morrill-LaBrode A, Dallal G
Department of Community Health, Tufts University School of Medicine, Boston, MA 02111.
Metabolism. 1989 Nov;38(11):1077-81. doi: 10.1016/0026-0495(89)90043-7.
Relationships between plasma levels of lipoproteins and sex hormones were studied in 24 healthy premenopausal women with no risk factors for coronary heart disease. The women were carefully selected to remove the effects of other environmental factors, such as smoking, drugs, alcohol, and exercise, which are known to influence lipid metabolism. They all ate precisely the same Western-style diet for 1 to 2 weeks before blood samples were obtained in the follicular phase of their menstrual cycle. After adjusting for other hormones by multiple regression, significant positive partial correlations were seen between high density lipoprotein cholesterol (HDL-C) and protein bound estradiol (r = .57, P = .02), as well as between very low density lipoprotein cholesterol (VLDL-C) and protein bound estradiol (r = .63, p = .01). A significant negative partial correlation was seen between VLDL-C and free estradiol (r = -.65 P = .01). Conversely, low density lipoprotein cholesterol (LDL-C) levels were negatively correlated with protein bound estradiol (r = -.77, P less than .001) and positively correlated with free estradiol (r = .71, P less than .001). No associations between plasma lipoproteins and testosterone were seen; however, androstenedione was positively correlated with VLDL-C (r = .59, P = .01). These findings show a close link between plasma lipoproteins and sex hormones, and may help to explain the lower risk of coronary heart disease in women.
对24名无冠心病危险因素的健康绝经前女性，研究了血浆脂蛋白水平与性激素之间的关系。这些女性经过精心挑选，以排除其他环境因素的影响，如吸烟、药物、酒精和运动，已知这些因素会影响脂质代谢。在月经周期的卵泡期采集血样前，她们都精确地食用相同的西式饮食1至2周。通过多元回归对其他激素进行校正后，发现高密度脂蛋白胆固醇（HDL-C）与蛋白结合雌二醇之间存在显著正偏相关（r = 0.57，P = 0.02），极低密度脂蛋白胆固醇（VLDL-C）与蛋白结合雌二醇之间也存在显著正偏相关（r = 0.63，p = 0.01）。VLDL-C与游离雌二醇之间存在显著负偏相关（r = -0.65，P = 0.01）。相反，低密度脂蛋白胆固醇（LDL-C）水平与蛋白结合雌二醇呈负相关（r = -0.77，P < 0.001），与游离雌二醇呈正相关（r = 0.71，P < 0.001）。然而，未发现血浆脂蛋白与睾酮之间存在关联；不过，雄烯二酮与VLDL-C呈正相关（r = 0.59，P = 0.01）。这些发现表明血浆脂蛋白与性激素之间存在密切联系，可能有助于解释女性冠心病风险较低的原因。
