Rougier M-B, Delyfer M-N, Korobelnik J-F
Service d'ophtalmologie, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France; Inserm, U1219, Bordeaux Population Health Research Center, 33000 Bordeaux, France.
Service d'ophtalmologie, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France; University Bordeaux, ISPED, 33000 Bordeaux, France; Inserm, U1219, Bordeaux Population Health Research Center, 33000 Bordeaux, France.
J Fr Ophtalmol. 2017 Feb;40(2):102-109. doi: 10.1016/j.jfo.2016.09.020. Epub 2017 Jan 20.
To describe changes of the retinal peripapillary microvasculature on optical coherence tomography angiography (OCT-A) in non-arteritic anterior ischemic optic (NAION) neuropathy.
Observational study of 10 patients at the acute phase of NAION. OCT-A was performed using a 3mm×3mm square centered on the optic disc (Cirrus HD-OCT with Angioplex, Carl Zeiss Meditec, Dublin, CA). A qualitative comparison was made with the healthy fellow eye of each patient. All patients had a fluorescein angiography (HRA2, Heidelberg, Germany) and a visual field examination (Octopus 101, Haag-Streit, USA).
In the affected eyes, OCT-A showed clear modifications in the radial peripapillary network. In all these eyes, a focal disappearance of the superficial capillary radial pattern was present, twisted and irregular. In 8 eyes, there was also a lack of vascularization in some focal areas, appearing as dark areas. No correlation was found between the topography of the vascular alteration shown on OCT-A and visual field pattern defects.
OCT-A is a new imaging technology able to demonstrate easily and safely the changes in the peripapillary capillary network during the acute phase of NAION. These changes are likely related to a decrease of the prelaminar optic nerve blood flow during the acute phase of NAION. Visual field defects are not correlated with OCT-A images, suggesting that they may be due mainly to disturbances in posterior ciliary artery blood flow.
描述非动脉炎性前部缺血性视神经病变（NAION）患者在光学相干断层扫描血管造影（OCT-A）下视网膜视乳头周围微血管的变化。
对10例处于NAION急性期的患者进行观察性研究。使用以视盘为中心的3mm×3mm正方形区域进行OCT-A检查（采用配备Angioplex的Cirrus HD-OCT，卡尔蔡司医疗技术公司，加利福尼亚州都柏林）。对每位患者的健侧眼进行定性比较。所有患者均接受了荧光素血管造影（德国海德堡HRA2）和视野检查（美国 Haag-Streit Octopus 101）。
在患眼中，OCT-A显示视乳头周围放射状网络有明显改变。在所有这些眼中，浅表毛细血管放射状模式存在局灶性消失，扭曲且不规则。8只眼中，某些局灶区域还存在血管化缺失，表现为暗区。OCT-A显示的血管改变部位与视野模式缺损之间未发现相关性。
OCT-A是一种新的成像技术，能够轻松、安全地显示NAION急性期视乳头周围毛细血管网络的变化。这些变化可能与NAION急性期视神经筛板前血流减少有关。视野缺损与OCT-A图像无关，提示它们可能主要是由于睫状后动脉血流紊乱所致。
