Syracuse Biomaterials Institute, Syracuse University, Syracuse, New York, 13244.
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York, 13244.
J Biomed Mater Res B Appl Biomater. 2018 Jan;106(1):209-220. doi: 10.1002/jbm.b.33830. Epub 2017 Jan 24.
Inflamed conditions may develop in total joint replacement applications and may impact on the corrosion of metallic biomaterials like CoCrMo alloy. The influence of simulated inflammatory (SI) conditions on the corrosion behavior of CoCrMo alloy was investigated. A range of SI solutions, based on phosphate buffered saline with H O , HCl, and Fe additions, were investigated. Open circuit potential (OCP), corrosion currents and impedance of the oxide film surface were all significantly (p < 0.05) affected by increases in H O concentration and decrease of pH. OCP (vs. Ag/AgCl) increased from -0.250 V in PBS solution to 0.355 V and 0.650 V in 30 mM H O at pH 7.4 and pH 1 PBS solution. Iron ions (0.1 mM) in PBS solutions with 10 mM H O (Fenton chemistry) increased OCP to 0.6 V. I increased from 0.2 µA/cm to 14 µA/cm in SI conditions. Electrochemical impedance spectroscopy showed decreased in oxide resistance (R , p < 0.05) while capacitance (CPE) increased (p < 0.05) in SI solutions, pH 7.4 (R = 5 × 10 Ω cm , CPE = 55 µF/cm ) as well as in Fenton reagent solution (R = 3.2 × 10 Ω cm , CPE = 45 µF/cm ) compared to PBS only (R = 5 × 10 Ω cm , CPE = 31 µF/cm ). These results indicate the corrosion susceptibility of CoCrMo alloy can be significantly increased by SI solutions, increasing the oxidizing power and decreasing the passivity of the oxide film. Cell-released chemicals such as H O and acid are able to facilitate the corrosion of CoCrMo alloy and demonstrate part of the mechanism of inflammatory cell induced corrosion. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 209-220, 2018.
在全关节置换应用中可能会出现炎症状态，这可能会影响 CoCrMo 合金等金属生物材料的腐蚀。研究了模拟炎症 (SI) 条件对 CoCrMo 合金腐蚀行为的影响。研究了一系列基于磷酸盐缓冲盐水 (PBS) 的 SI 溶液，其中添加了 H2O2、HCl 和 Fe。开路电位 (OCP)、腐蚀电流和氧化膜表面阻抗均受到 H2O2 浓度增加和 pH 值降低的显著影响 (p < 0.05)。OCP (相对于 Ag/AgCl) 从 PBS 溶液中的-0.250 V 增加到 30 mM H2O2 在 pH 7.4 和 pH 1 的 PBS 溶液中的 0.355 V 和 0.650 V。在含有 10 mM H2O2 的 PBS 溶液中 (Fenton 化学) 的铁离子 (0.1 mM) 将 OCP 增加到 0.6 V。在 SI 条件下，I 从 0.2 µA/cm 增加到 14 µA/cm。电化学阻抗谱显示，在 SI 溶液中，氧化电阻 (R，p < 0.05) 降低，而电容 (CPE) 增加 (p < 0.05)，在 pH 7.4 (R = 5 × 10 Ω cm，CPE = 55 µF/cm ) 以及 Fenton 试剂溶液中 (R = 3.2 × 10 Ω cm，CPE = 45 µF/cm ) 与仅 PBS 相比 (R = 5 × 10 Ω cm，CPE = 31 µF/cm )。这些结果表明，SI 溶液会显著增加 CoCrMo 合金的腐蚀性，从而提高氧化能力并降低氧化膜的钝化性。细胞释放的化学物质，如 H2O2 和酸，能够促进 CoCrMo 合金的腐蚀，并证明了炎症细胞诱导腐蚀的部分机制。© 2016 Wiley Periodicals, Inc. J 生物材料 Res 部分 B: 应用生物材料，106B:209-220，2018。
