Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, People's Republic of China.
J Nanobiotechnology. 2019 Apr 16;17(1):55. doi: 10.1186/s12951-019-0488-9.
Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. In this study, we explored the corrosion behaviors of four common materials (commercially pure Ti, cp-Ti; Sandblasting and acid etching-modified Ti, Ti-SLA; nanowires-modified Ti, Ti-NW; and zinc-containing nanowires-modified Ti, Ti-NW-Zn) with excellent biocompatibilities and osteogenic capacities under the macrophages induced-oxidizing microenvironment. The results showed that the materials immersed into a high oxidizing environment were more vulnerable to corrode. Meanwhile, different surfaces also showed various corrosion susceptibilities under oxidizing condition. Samples embed with zinc element exhibited more excellent corrosion resistance compared with other three surfaces exposure to excessive HO. Besides, we found that zinc-decorated Ti surfaces inhibited the adhesion and proliferation of macrophages on its surface and induced the M2 states of macrophages to better healing and tissue reconstruction. Most importantly, zinc-decorated Ti surfaces markedly increased the expressions of antioxidant enzyme relative genes in macrophages. It improved the oxidation microenvironment around the materials and further protected their properties. In summary, our results demonstrated that Ti-NW-Zn surfaces not only provided excellent corrosion resistance properties, but also inhibited the adhesion of macrophages. These aspects were necessary for maintaining osseointegration capacity and enhancing the corrosion resistance of Ti in numerous medical applications, particularly in dentistry.
钛（Ti）及其合金作为生物植入物，经过化学组成和形貌的各种方法改性后，具有优异的生物相容性和成骨性能。这些改性材料的耐腐蚀性对于改变口腔系统非常重要，但很少有研究报道这一点。最近，细胞代谢物引起的氧化腐蚀受到了广泛关注。在这项研究中，我们在巨噬细胞诱导的氧化微环境下，探索了具有优异生物相容性和成骨能力的四种常见材料（商业纯钛、Ti-SLA、Ti-NW 和 Ti-NW-Zn）的腐蚀行为。结果表明，浸泡在高氧化环境中的材料更容易腐蚀。同时，不同的表面在氧化条件下也表现出不同的腐蚀敏感性。与其他三种表面相比，含有锌元素的样品在暴露于过量 HO 时表现出更好的耐腐蚀性。此外，我们发现锌修饰的 Ti 表面抑制了巨噬细胞在其表面的黏附和增殖，并诱导巨噬细胞向 M2 状态转化，从而更好地促进愈合和组织重建。最重要的是，锌修饰的 Ti 表面显著增加了巨噬细胞中抗氧化酶相关基因的表达。它改善了材料周围的氧化微环境，进一步保护了它们的性能。总之，我们的结果表明，Ti-NW-Zn 表面不仅提供了优异的耐腐蚀性，还抑制了巨噬细胞的黏附。这些方面对于维持骨整合能力和增强钛在众多医学应用中的耐腐蚀性是必要的，特别是在牙科领域。
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