Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
National Engineering Research Center for Nanomedicine and College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074, China.
ACS Nano. 2017 Feb 28;11(2):1848-1857. doi: 10.1021/acsnano.6b07866. Epub 2017 Jan 31.
AgS nanoparticles are increasingly important in biomedicine, such as in cancer imaging. However, there has been only limited success in the exploration of theranostic AgS nanoparticles for photoinduced cancer imaging and simultaneous therapy. Here we report size-dependent AgS nanodots (NDs) with well-defined nanostructure as a theranostic agent for multimodal imaging and simultaneous photothermal therapy. The NDs are precisely synthesized through carefully controlled growth of AgS in hollow human serum albumin nanocages. These NDs produce effective fluorescence in second near-infrared (NIR-II) region, distinct photoacoustic intensity, and good photothermal conversion in a size-dependent manner under light irradiation, thereby generating sufficient in vivo fluorescence and photoacoustic signals as well as potent hyperthermia at tumors. Moreover, AgS NDs possess ideal resistance to photobleaching, effective cellular uptake, preferable tumor accumulation, and in vivo elimination, thus facilitating NIR-II fluorescence/photoacoustics imaging with both ultrasensitivity and microscopic spatial resolution and simultaneous photothermal tumor ablation. These findings provide insight into the clinical potential of AgS nanodots for cancer theranostics.
AgS 纳米颗粒在生物医药领域越来越重要，例如在癌症成像中。然而，对于用于光诱导癌症成像和同时治疗的治疗性 AgS 纳米颗粒的探索，仅有有限的成功。在这里，我们报告了具有明确定义的纳米结构的尺寸依赖性 AgS 纳米点 (NDs)，作为一种用于多模态成像和同时光热治疗的治疗剂。这些 NDs 是通过在中空人血清白蛋白纳米笼中仔细控制 AgS 的生长精确合成的。这些 NDs 在光照下以尺寸依赖性的方式产生有效的近红外二区 (NIR-II) 荧光、明显的光声强度和良好的光热转换，从而在肿瘤部位产生足够的体内荧光和光声信号以及有效的高热疗。此外，AgS NDs 具有理想的抗光漂白性、有效的细胞摄取、良好的肿瘤积累和体内消除能力，从而促进了具有超高灵敏度和微观空间分辨率的近红外二区荧光/光声成像以及同时的光热肿瘤消融。这些发现为 AgS 纳米点在癌症治疗中的临床应用提供了新的见解。
