Vickers Barbara A, Lee Wayne, Hunsberger Joann
From the Division of Pediatric Anesthesiology, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
A A Case Rep. 2017 May 1;8(9):219-221. doi: 10.1213/XAA.0000000000000472.
Oncology patients undergoing treatment can experience substantial pain related to their disease or prescribed therapy. Ketamine infusions at subanesthetic doses have been used at our institution to supplement the pain management regimens of 262 patients. We present 2 cases in which young adult patients being treated with subanesthetic ketamine for cancer-related pain experienced urinary urgency and incontinence after initiation or increase of the ketamine infusion. This adverse effect has not been reported previously at this dosing range. These case reports suggest that subanesthetic ketamine infusions may cause side effects that previously have been reported only at anesthetic or abuse doses.
正在接受治疗的肿瘤患者可能会经历与疾病或规定治疗相关的剧痛。我院已使用亚麻醉剂量的氯胺酮输注来补充262例患者的疼痛管理方案。我们报告2例年轻成年患者，他们因癌症相关疼痛接受亚麻醉剂量氯胺酮治疗，在开始输注或增加氯胺酮剂量后出现尿急和尿失禁。此前尚未在该剂量范围内报道过这种不良反应。这些病例报告表明，亚麻醉剂量的氯胺酮输注可能会引起一些副作用，而这些副作用以前仅在麻醉或滥用剂量下才有报道。
