From the Department of Anesthesiology, Pain Management Center, University of Virginia Health System, Charlottesville, Virginia.
A A Pract. 2020 Jun;14(8):e01239. doi: 10.1213/XAA.0000000000001239.
Intravenous infusion of a subanesthetic dose of ketamine has been shown to improve neuropathic pain. However, ketamine-induced liver injury can occur. Reported here are 2 cases with substantial liver enzyme elevations less than 2 days after initiation of repeat ketamine infusion at least 7 months after the last infusion. Although their liver enzymes normalized within a few weeks, it is unclear what the long-term consequences are. Furthermore, drug-induced liver injury can cause acute liver failure. Therefore, we recommend close monitoring of liver enzymes every 1 to 2 days during ketamine infusions.
静脉输注亚麻醉剂量的氯胺酮已被证明可改善神经性疼痛。然而，氯胺酮可引起肝损伤。本文报告了 2 例患者，在末次输注氯胺酮至少 7 个月后再次输注氯胺酮至少 7 个月后，在开始输注后不到 2 天，肝酶显著升高。尽管他们的肝酶在数周内恢复正常，但尚不清楚长期后果如何。此外，药物性肝损伤可导致急性肝衰竭。因此，我们建议在输注氯胺酮期间每 1 至 2 天密切监测肝酶。
